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PMID: 7474117 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Isolation and characterization of a new simian T-cell leukemia virus type 1 from naturally infected celebes macaques (Macaca tonkeana): complete nucleotide sequence and phylogenetic relationship with the Australo-Melanesian human T-cell leukemia virus type 1.

Journal of virology ·Vol. 69 ·No. 11 ·1995-11-00 ·Pages 6980-93

Ibrahim F, de Thé G, Gessain A

Abstract

A study of simian T-cell leukemia virus type 1 (STLV-1) infection in a captive colony of 23 Macaca tonkeana macaques indicated that 17 animals had high human T-cell leukemia virus type 1 (HTLV-1) antibody titers. Genealogical analysis suggested mainly a mother-to-offspring transmission of this STLV-1. Three long-term T-cell lines, established from peripheral blood mononuclear cell cultures from three STLV-1-seropositive monkeys, produced HTLV-1 Gag and Env antigens and retroviral particles. The first complete nucleotide sequence of an STLV-1 (9,025 bp), obtained for one of these isolates, indicated an overall genetic organization similar to that of HTLV-1 but with a nucleotide variability for the structural genes ranging from 7.8 to 13.1% compared with the HTLV-1 ATK and STLV-1 PTM3 Asian prototypes. The Tax and Rex regulatory proteins were well conserved, while the pX region, known to encode new proteins in HTLV-1 (open reading frames I and II), was more divergent than that in the ATK strain. Furthermore, a fragment of 522 bp of the gp21 env gene from uncultured peripheral blood mononuclear cell DNAs from five of the STLV-1-infected monkeys was sequenced. Phylogenetic trees constructed with the long terminal repeat and env (gp46 and gp21) regions demonstrated that this new STLV-1 occupies a unique position within the Asian STLV-1 and HTLV-1 isolates, being, by most analyses, related more to the Australo-Melanesian HTLV-1 topotype than to any other Asian STLV-1. These data raise new hypotheses on the possible interspecies viral transmission between monkeys carrying STLV-1 and early Australoid settlers, ancestors of the present day Australo-Melanesian inhabitants, during their migrations from the Southeast Asian land mass to the greater Australian continent.

MeSH Terms
Amino Acid Sequence Animals Antigens, Viral/analysis Australia Base Sequence Binding Sites Cloning, Molecular DNA Primers Deltaretrovirus Infections/virology Enhancer Elements, Genetic Female Gene Products, rex/metabolism Human T-lymphotropic virus 1/classification,genetics Humans Macaca/genetics,virology Male Melanesia Molecular Sequence Data Pedigree Phylogeny Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Simian T-lymphotropic virus 1/classification,genetics,isolation & purification TATA Box
Chemicals
Antigens, Viral DNA Primers Gene Products, rex
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ibrahim F
Unité d'Epidémiologie des Virus Oncogènes, Institut Pasteur, France.
de Thé G
Gessain A
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.69.11.6980-6993.1995
Published
1995-11-00
Pages
6980-93
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC189617
Subset
IM
Databases
GENBANK
Z46895, Z46896, Z46897, Z46898, Z46899, Z46900
External Links
PubMed source DOI: 10.1128/JVI.69.11.6980-6993.1995 PMC Full Text View journal details
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