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PMID: 7433104 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Circular dichroism spectra show that repeating dinucleotide DNAs may form helices in which every other base is looped out.

Nucleic acids research ·Vol. 8 ·No. 16 ·1980-08-25 ·Pages 3695-707

Gray DM, Vaughan M

Abstract

We have found that the CD spectrum of poly [d(C-T)] undergoes a marked change upon protonation, taking on the unmistakable features of the spectrum of poly[d(C) x d(C+)]. The acid poly[d9C-T)] structure appears to be one in which each of the T residues is individually looped out of a helix formed by stacked C x C+ base pairs. We also present data for poly[d(C-A)] and review data for the other four possible repeating DNA dinucleotide sequences. These data show that self-complexes in which up to 50% of the residues are extrahelical may be unexceptional.

MeSH Terms
Circular Dichroism DNA Nucleic Acid Conformation Polydeoxyribonucleotides Repetitive Sequences, Nucleic Acid Structure-Activity Relationship
Chemicals
Polydeoxyribonucleotides DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gray D M
Vaughan M
References (21)
21 references, click to expand
  1. Polyriboadenylic and polydeoxyriboadenylic acids. Optical rotatory studies of pH-dependent conformations and their relative stability.
    Biochemistry. 1969 Sep;8(9):3846-59 PMID: 5820670
  2. Oligonucleotide interactions. 3. Circular dichroism studies of the conformation of deoxyoligonucleotides.
    Biopolymers. 1970;9(9):1059-77 PMID: 5449435
  3. Thermal transitions in mixtures of polydeoxyribodinucleotides.
    Biopolymers. 1970;9(9):1105-17 PMID: 5449437
  4. Salt-induced co-operative conformational change of a synthetic DNA: equilibrium and kinetic studies with poly (dG-dC).
    J Mol Biol. 1972 Jun 28;67(3):375-96 PMID: 5045303
  5. A wobbly double helix.
    Nat New Biol. 1973 Aug 8;244(136):169-70 PMID: 4516446
  6. A circular dichroism study of poly dG, poly dC, and poly dG:dC.
    Biopolymers. 1974;13(10):2087-102 PMID: 4433702
  7. X-ray fiber diffraction and model-building study of polyguanylic acid and polyinosinic acid.
    J Mol Biol. 1975 Feb 25;92(2):181-92 PMID: 1142423
  8. Circular dichroism spectra of poly[d(AC):d(GT)], poly[r(AC):r(GU)], and hybrids poly[d(AC):r(GU)] and poly[r(AC):d(GT)] in the presence of ethanol.
    Biopolymers. 1975 Mar;14(3):487-98 PMID: 1174677
  9. Polymorphism of a synthetic DNA in solution.
    Nature. 1976 Mar 25;260(5549):365-6 PMID: 1256581
  10. Base pairing and fidelity in codon-anticodon interaction.
    Nature. 1976 Sep 23;263(5575):289-93 PMID: 958483
  11. Circular dichroism evidence for G-U and G-T base pairing in poly[r(G-U)] and poly[d(G-T)].
    Biopolymers. 1977 Jun;16(6):1331-42 PMID: 880358
  12. Base pairing structure in the poly d(G-T) double helix: wobble base pairs.
    Nucleic Acids Res. 1978 Jun;5(6):1955-70 PMID: 673842
  13. Protonated polynucleotides structures - 22.CD study of the acid-base titration of poly(dG).poly(dC).
    Nucleic Acids Res. 1978 Jun;5(6):1979-96 PMID: 27761
  14. Protonated polynucleotides structures - 23. The acid-base hysteresis of poly(dG).poly(dC).
    Nucleic Acids Res. 1978 Jun;5(6):1997-2012 PMID: 27762
  15. A comparison of the circular dichroism spectra of synthetic DNA sequences of the homopurine . homopyrimidine and mixed purine- pyrimidine types.
    Nucleic Acids Res. 1978 Oct;5(10):3679-95 PMID: 31602
  16. "Alternating B-DNA" conformation for the oligo(dG-dC) duplex in high-salt solution.
    Proc Natl Acad Sci U S A. 1979 Jun;76(6):2508-11 PMID: 288040
  17. Complexes formed by (pyrimidine)n . (purine)n DNAs on lowering the pH are three-stranded.
    Nucleic Acids Res. 1979 Jul 11;6(9):3073-91 PMID: 40208
  18. Molecular structure of a left-handed double helical DNA fragment at atomic resolution.
    Nature. 1979 Dec 13;282(5740):680-6 PMID: 514347
  19. Left-handed DNA helices.
    Nature. 1980 Feb 21;283(5749):743-5 PMID: 7354864
  20. Molecular structure of helical polycytidylic acid.
    Nature. 1963 May 25;198:725-8 PMID: 13928676
  21. TRANSITIONS OF DNA HOMOPOLYMERS.
    J Mol Biol. 1964 Sep;9:624-37 PMID: 14216607
Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/8.16.3695
Published
1980-08-25
Pages
3695-707
Language
English
Region
England
NLM ID
0411011
PMCID
PMC324184
Subset
IM
Grants
NIGMS NIH HHS · GM 19060 · United States
External Links
PubMed source DOI: 10.1093/nar/8.16.3695 PMC Full Text View journal details
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