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PMID: 514347 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Molecular structure of a left-handed double helical DNA fragment at atomic resolution.

Nature ·Vol. 282 ·No. 5740 ·1979-12-13 ·Pages 680-6

Wang AH, Quigley GJ, Kolpak FJ, Crawford JL, van Boom JH, van der Marel G, Rich A

Abstract

The DNA fragment d(CpGpCpGpCpG) crystallises as a left-handed double helical molecule with Watson-Crick base pairs and an antiparallel organisation of the sugar phosphate chains. The helix has two nucleotides in the asymmetric unit and contains twelve base pairs per turn. It differs significantly from right-handed B-DNA.

MeSH Terms

Base Sequence Crystallization DNA Hydrogen Bonding Nucleic Acid Conformation Polydeoxyribonucleotides Structure-Activity Relationship X-Ray Diffraction

Chemicals

Polydeoxyribonucleotides DNA

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Wang A H

Quigley G J

Kolpak F J

Crawford J L

van Boom J H

van der Marel G

Rich A

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/282680a0

Published

1979-12-13

Pages

680-6

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/282680a0 View journal details

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Molecular structure of a left-handed double helical DNA fragment at atomic resolution.

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