Cimetidine and prolonged post-operative somnolence.

Canadian Anaesthetists' Society journal ·Vol. 28 ·No. 5 ·1981-09-00 ·Pages 450-2

Lam AM, Parkin JA

Abstract

A case of prolonged post-operative somnolence is described. The patient was on concurrent benzodiazepine and cimetidine therapy. Cimetidine can cause impairment of metabolism of the benzodiazepines by inhibiting the hepatic microsomal enzyme system and its possible role in causing the prolonged somnolence is discussed.

MeSH Terms

Aged Cimetidine/adverse effects Guanidines/adverse effects Humans Male Oxazepam/adverse effects Postoperative Complications/chemically induced Sleep Wake Disorders/chemically induced

Chemicals

Guanidines Oxazepam Cimetidine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Lam A M

Parkin J A

References (18)

18 references, click to expand

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Pre-anesthetic cimetidine alteration of gastric fluid volume and pH.
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N Engl J Med. 1979 May 3;300(18):1012-5 PMID: 431595
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Article Info

Journal

Canadian Anaesthetists' Society journal

Abbr.

Can Anaesth Soc J

ISSN

0008-2856

DOI

10.1007/BF03010354

Published

1981-09-00

Pages

450-2

Language

English

Region

Canada

NLM ID

0371163

Subset

External Links

PubMed source DOI: 10.1007/BF03010354

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Cimetidine and prolonged post-operative somnolence.

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