Development of acute opioid tolerance and dependence in rat striatal neurones.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 313 ·No. 2 ·1980-08-00 ·Pages 145-9

Fry JP, Zieglgänsberger W, Herz A

Abstract

Striatal neurones in the rat were frequently observed to develop tachyphylaxis to the specific, naloxone-antagonisable depressant effects of methionine- and leucine-enkephalin on spontaneous and L-glutamate-evoked activity. This loss of responsiveness to the enkephalins occurred within a few minutes of the repeated or prolonged application of these peptides and is suggested to reflect a form of acute tolerance. As with chronic opiate tolerance, the acute tolerance of single striatal neurones to the enkephalins appeared to be associated with dependence on these opioids, as evinced by the withdrawal-like hyperactivity that occurred upon terminating the application of the peptides or upon the microelectrophoresis of naloxone.

MeSH Terms

Animals Corpus Striatum/physiopathology Drug Tolerance Enkephalins/pharmacology Glutamates/pharmacology Humans Male Naloxone/pharmacology Narcotics/pharmacology Neurons/drug effects,physiopathology Opioid-Related Disorders/physiopathology Rats

Chemicals

Enkephalins Glutamates Narcotics Naloxone

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Fry J P

Zieglgänsberger W

Herz A

References (27)

27 references, click to expand

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Article Info

Journal

Naunyn-Schmiedeberg's archives of pharmacology

Abbr.

Naunyn Schmiedebergs Arch Pharmacol

ISSN

0028-1298

DOI

10.1007/BF00498571

Published

1980-08-00

Pages

145-9

Language

English

Region

Germany

NLM ID

0326264

Subset

External Links

PubMed source DOI: 10.1007/BF00498571 View journal details

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Development of acute opioid tolerance and dependence in rat striatal neurones.

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