Radioimmunoassay of enkephalins. Regional distribution in rat brain after morphine treatment and hypophysectomy.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 301 ·No. 1 ·1977-12-00 ·Pages 79-82

Wesche D, Höllt V, Herz A

Abstract

Using highly sensitive and highly specific antisera methionine- and leucine-enkephalin levels were determined in various areas of the rat brain. The highest content of both enkephalins was found in the striatum and the hypothalamus, whereas in the hippocampus, the cerebellum and the cortex only a low content was present. The ratio methionine-enkephalin/leucine-enkephalin was about three. Neither acute or chronic morphine treatment nor precipitated morphine withdrawal induced significant changes in enkephalin levels in any brain region. Also hypophysectomy did not affect the enkephalin content of the various brain regions.

MeSH Terms

Animals Brain Chemistry/drug effects Endorphins/analysis Enkephalins/analysis Female Humans Hypophysectomy Morphine/pharmacology Morphine Dependence/metabolism Radioimmunoassay Rats

Chemicals

Endorphins Enkephalins Morphine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Wesche D

Höllt V

Herz A

References (12)

12 references, click to expand

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Article Info

Journal

Naunyn-Schmiedeberg's archives of pharmacology

Abbr.

Naunyn Schmiedebergs Arch Pharmacol

ISSN

0028-1298

DOI

10.1007/BF00501267

Published

1977-12-00

Pages

79-82

Language

English

Region

Germany

NLM ID

0326264

Subset

External Links

PubMed source DOI: 10.1007/BF00501267 View journal details

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Radioimmunoassay of enkephalins. Regional distribution in rat brain after morphine treatment and hypophysectomy.

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