Home LiteratureArticle Details
PMID: 7124733 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Genetic evidence for the inactivation of a human autosomal locus attached to an inactive X chromosome.

American journal of human genetics ·Vol. 34 ·No. 5 ·1982-09-00 ·Pages 811-7

Mohandas T, Sparkes RS, Shapiro LJ

Abstract

Mouse-human cell hybrid clones retaining an inactive translocated chromosome involving the human X and 13 were isolated. Esterase D, a marker on the segment of chromosome 13 translocated to the X, was not expressed in these clones. These results provide genetic evidence for the spreading of inactivation into the autosomal segment in an inactive human X-autosome translocation.

MeSH Terms
Animals Carboxylesterase Carboxylic Ester Hydrolases/genetics Cell Line Chromosomes, Human, 13-15 Clone Cells/enzymology Dosage Compensation, Genetic Female Glucosephosphate Dehydrogenase/genetics Humans Hybrid Cells/enzymology Mice Sex Chromosomes Translocation, Genetic X Chromosome
Chemicals
Glucosephosphate Dehydrogenase Carboxylic Ester Hydrolases Carboxylesterase ESD protein, human
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Mohandas T
Sparkes R S
Shapiro L J
References (23)
23 references, click to expand
  1. Gene action in the X-chromosome of the mouse (Mus musculus L.).
    Nature. 1961 Apr 22;190:372-3 PMID: 13764598
  2. Genetics of human cell line. IV. DNA-mediated heritable transformation of a biochemical trait.
    Proc Natl Acad Sci U S A. 1962 Dec 15;48:2026-34 PMID: 13980043
  3. SELECTION OF HYBRIDS FROM MATINGS OF FIBROBLASTS IN VITRO AND THEIR PRESUMED RECOMBINANTS.
    Science. 1964 Aug 14;145(3633):709-10 PMID: 14168277
  4. Cellulose acetate electrophoresis of human glucose-6-phosphate dehydrogenase.
    J Lab Clin Med. 1969 Mar;73(3):531-4 PMID: 4179685
  5. Electrophoresis of phosphoglycerate kinase.
    Biochem Genet. 1969 Apr;3(2):189-95 PMID: 5364926
  6. X-autosome translocations in the mouse: total inactivation versus partial inactivation of the X chromosome.
    Adv Genet. 1970;15:175-259 PMID: 4936423
  7. Further proof of genetic inactivation of the X chromosome in the female mule.
    Nature. 1972 Jun 16;237(5355):393-6 PMID: 4557323
  8. G6PD expression and X chromosome late replication in fibroblast clones from a female mule.
    Nature. 1972 Jun 16;237(5355):396-7 PMID: 4557324
  9. Esterase D: a new human polymorphism.
    Ann Hum Genet. 1973 Oct;37(2):119-37 PMID: 4768551
  10. A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.
    Eur J Biochem. 1974 Jul 1;46(1):83-8 PMID: 4850204
  11. Chromosome assignment of some human enzyme loci: mitochondrial malate dehydrogenase to 7, mannosephosphate isomerase and pyruvate kinase to 15 and probably, esterase D to 13.
    Ann Hum Genet. 1975 Jan;38(3):295-303 PMID: 1137344
  12. Assigment of human esterase-D gene to chromosome 13.
    Cytogenet Cell Genet. 1975;14(3-6):269-72 PMID: 1192800
  13. Chromosomal anomalies in patients with retinoblastoma.
    Clin Genet. 1977 Jul;12(1):1-8 PMID: 891004
  14. Retinoblastoma in a patient with a 13qXp translocation.
    Am J Ophthalmol. 1977 Oct;84(4):548-54 PMID: 910860
  15. Assignment of the human gene for galactose-1-phosphate uridyltransferase to chromosome 9: studies with Chinese hamster-human somatic cell hybrids.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5628-31 PMID: 271990
  16. Human and mouse hypoxanthine-guanine phosphoribosyltransferase: dimers and tetramers.
    Science. 1979 Jan 12;203(4376):174-6 PMID: 569362
  17. Retinoblastoma with 13q- chromosomal deletion associated with maternal paracentric inversion of 13q.
    Science. 1979 Mar 9;203(4384):1027-9 PMID: 424728
  18. Evidence for a correlation between late replication and autosomal gene inactivation in a familial translocation t(X;21).
    Hum Genet. 1979 Jul 18;49(3):319-26 PMID: 157971
  19. Late replication in an X-autosome translocation in the mouse: correlation with genetic inactivation and evidence for selective effects during embryogenesis.
    Proc Natl Acad Sci U S A. 1979 Oct;76(10):5234-8 PMID: 291940
  20. Regional assignment of the steroid sulfatase-X-linked ichthyosis locus: implications for a noninactivated region on the short arm of human X chromosome.
    Proc Natl Acad Sci U S A. 1979 Nov;76(11):5779-83 PMID: 293682
  21. Regional assignment of genes for human esterase D and retinoblastoma to chromosome band 13q14.
    Science. 1980 May 30;208(4447):1042-4 PMID: 7375916
  22. Further observations on a 13qXp translocation associated with retinoblastoma.
    Am J Ophthalmol. 1980 May;89(5):621-7 PMID: 7189644
  23. Reactivation of an inactive human X chromosome: evidence for X inactivation by DNA methylation.
    Science. 1981 Jan 23;211(4480):393-6 PMID: 6164095
Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1982-09-00
Pages
811-7
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1685441
Subset
IM
Grants
NICHD NIH HHS · HD-04612 · United States
NICHD NIH HHS · HD-05616 · United States
NICHD NIH HHS · HD-12178 · United States
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2