Hepatic blood flow and drug metabolism in patients on enzyme-inducing anticonvulsants.

European journal of clinical pharmacology ·Vol. 22 ·No. 5 ·1982-00-00 ·Pages 441-5

Pirttiaho HI, Sotaniemi EA, Pelkonen RO, Pitkänen U

Abstract

Liver blood flow and indices of hepatic drug metabolism (antipyrine elimination rate and cytochrome P-450 concentration in liver biopsy specimens) were studied in 19 epileptics on long-term anticonvulsant treatment, and in 18 controls. The size of the liver and the total estimated liver blood flow were greater inthe epileptics than in the controls, whereas the relative liver blood flow (per unit weight of the liver) was not significantly different. The epileptics had higher cytochrome P-450 levels and they eliminated antipyrine faster than the controls. It was concluded that long-term ingestion of enzyme-inducing anticonvulsants is associated with an increase in the total hepatic blood flow in parallel with the increase in liver size, and not as an independent phenomenon. Since the relative perfusion rate of the hepatocytes was unchanged, the enhanced activity of drug metabolizing enzymes is presumed to be mainly responsible for the increased drug clearance observed in epileptic subjects.

MeSH Terms

Adult Anticonvulsants/adverse effects,therapeutic use Antipyrine/metabolism Cytochrome P-450 Enzyme System/metabolism Enzyme Induction/drug effects Female Half-Life Humans Liver Circulation/drug effects Male Middle Aged Organ Size/drug effects Pharmaceutical Preparations/metabolism

Chemicals

Anticonvulsants Pharmaceutical Preparations Cytochrome P-450 Enzyme System Antipyrine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Pirttiaho H I

Sotaniemi E A

Pelkonen R O

Pitkänen U

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22 references, click to expand

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Article Info

Journal

European journal of clinical pharmacology

Abbr.

Eur J Clin Pharmacol

ISSN

0031-6970

DOI

10.1007/BF00542550

Published

1982-00-00

Pages

441-5

Language

English

Region

Germany

NLM ID

1256165

Subset

External Links

PubMed source DOI: 10.1007/BF00542550 View journal details

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Hepatic blood flow and drug metabolism in patients on enzyme-inducing anticonvulsants.

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