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PMID: 5087064 Published · ppublish English Journal Article

The stimulant effect of drugs on indocyanine green clearance by the liver.

Gut ·Vol. 13 ·No. 10 ·1972-10-00 ·Pages 755-8

Melikian V, Eddy JD, Paton A

Abstract

The rate of removal of a standard dose of 25 mg indocyanine green was studied in 67 patients at the bedside using dichromatic ear densitometry. The determination of the percentage disappearance rate per minute and the half life of the dye permitted separation of patients into three groups: those with normal liver function, those with liver damage, and a group taking opiates (9), anticonvulsants (8), phenylbutazone (2), haloperidol (1), and nitrofurantoin (1). The last group showed enhanced clearance of indocyanine green from the circulation.

MeSH Terms
Adult Aged Anticonvulsants/therapeutic use Densitometry Drug Therapy Ear, External Female Half-Life Haloperidol/therapeutic use Hepatitis/metabolism Heroin Humans Indocyanine Green/metabolism Liver/metabolism Liver Cirrhosis/metabolism Male Meperidine Middle Aged Morphine Nitrofurantoin/therapeutic use Phenylbutazone/therapeutic use Stimulation, Chemical Substance-Related Disorders/metabolism
Chemicals
Anticonvulsants Heroin Morphine Nitrofurantoin Meperidine Phenylbutazone Indocyanine Green Haloperidol
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Melikian V
Eddy J D
Paton A
References (12)
12 references, click to expand
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    Clin Sci. 1961 Aug;21:43-57 PMID: 13689739
  2. Studies of hepatic function with indocyanine green.
    Gastroenterology. 1960 Dec;39:713-24 PMID: 13716911
  3. Excretion of nitrofurantoin in dog hepatic bile.
    Br J Pharmacol. 1971 Sep;43(1):140-50 PMID: 5136454
  4. Indocyanine green clearance as a test for hepatic function. Evaluation by dichromatic ear densitometry.
    JAMA. 1967 Apr 17;200(3):236-40 PMID: 6071462
  5. Effect of probenecid on indocyanine green clearance.
    J Pharmacol Exp Ther. 1966 Jun;152(3):509-15 PMID: 5922315
  6. Use of indocyanine green as a test of liver function.
    Am J Dig Dis. 1963 Mar;8:244-50 PMID: 14022792
  7. Hepatic uptake and biliary excretion of indocyanine green in the dog.
    Proc Soc Exp Biol Med. 1958 Oct;99(1):11-4 PMID: 13601749
  8. Studies of Y and Z, two hepatic cytoplasmic organic anion-binding proteins: effect of drugs, chemicals, hormones, and cholestasis.
    J Clin Invest. 1971 Nov;50(11):2242-52 PMID: 5096510
  9. Measurement of acute changes in liver function and blood flow.
    Arch Surg. 1970 May;100(5):541-5 PMID: 4908947
  10. A tricarbocyanine dye for continuous recording of dilution curves in whole blood independent of variations in blood oxygen saturation.
    Proc Staff Meet Mayo Clin. 1957 Sep 4;32(18):478-84 PMID: 13465828
  11. Indocyanine green: observations on its physical properties, plasma decay, and hepatic extraction.
    J Clin Invest. 1960 Apr;39:592-600 PMID: 13809697
  12. Phenylbutazone and isoniazid metabolism in patients with liver disease in relation to previous drug therapy.
    Lancet. 1968 Jun 15;1(7555):1275-9 PMID: 4172137
Article Info
Journal
Gut
Abbr.
Gut
ISSN
0017-5749
DOI
10.1136/gut.13.10.755
Published
1972-10-00
Pages
755-8
Language
English
Region
England
NLM ID
2985108R
PMCID
PMC1412483
Subset
IM
External Links
PubMed source DOI: 10.1136/gut.13.10.755 PMC Full Text View journal details
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