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PMID: 7027923 Published · ppublish English Clinical Trial Journal Article Randomized Controlled Trial

Bacteriological aspects of selective decontamination of the digestive tract as a method of infection prevention in granulocytopenic patients.

Antimicrobial agents and chemotherapy ·Vol. 19 ·No. 5 ·1981-05-00 ·Pages 813-20

de Vries-Hospers HG, Sleijfer DT, Mulder NH, van der Waaij D, Neiweg HO, van Saene HK

Abstract

We describe the bacteriological results of a controlled clinical trial of selective decontamination of the digestive tract as a method of infection prevention in granulocytopenic patients. Selective elimination of Enterobacteriaceae and Pseudomonadaceae species was accomplished by the oral administration of nalidixic acid, co-trimoxazole, or polymyxin. Yeasts were eliminated selectively by amphotericin B or nystatin treatment. The drugs used in this study were chosen because of their capacities to selectively eliminate gram-negative rods and yeast without affecting the anaerobic part of the gut flora which is responsible for colonization resistance. Compared with the control group, the selectively decontaminated patients had significantly fewer (P less than 0.0005) gram-negative rods or yeasts or both in their throat swab cultures and in their feces. This reduction may explain the clinical effectiveness of selective decontamination.

MeSH Terms
Agranulocytosis/complications Anti-Bacterial Agents/pharmacology,therapeutic use Clinical Trials as Topic Cross Infection/prevention & control Digestive System/microbiology Drug Resistance, Microbial Enterobacteriaceae/classification,drug effects Feces/microbiology Humans Pharynx/microbiology Pseudomonadaceae/classification,drug effects
Chemicals
Anti-Bacterial Agents
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
de Vries-Hospers H G
Sleijfer D T
Mulder N H
van der Waaij D
Neiweg H O
van Saene H K
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.19.5.813
Published
1981-05-00
Pages
813-20
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC181528
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.19.5.813 PMC Full Text View journal details
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