Partial antibiotic decontamination.

British medical journal ·Vol. 1 ·No. 6064 ·1977-03-26 ·Pages 800-2

Guiot HF, Furth R

Abstract

Partial antibiotic decontamination and reverse isolation were carried out in nine patients undergoing bone marrow transplantation. The aim of this approach was to eradicate the patient's endogenous potentially pathogenic bacteria while preserving the anaerobic flora of the gut, which help to prevent recolonisation. No exogenous infections developed, and only one patient developed an infection associated with endogenous recolonisation. Colonisation resistance seemed normal in patients during partial antibiotic decontamination. This form of decontamination deserves further study in patients with immunodepression.

MeSH Terms

Adolescent Adult Anti-Bacterial Agents/therapeutic use Bacterial Infections/prevention & control Bone Marrow Cells Bone Marrow Transplantation Female Gram-Negative Aerobic Bacteria/isolation & purification Humans Male Patient Isolation

Chemicals

Anti-Bacterial Agents

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Guiot H F

Furth R

References (9)

9 references, click to expand

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Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.1.6064.798-a

Published

1977-03-26

Pages

800-2

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1606145

Subset

External Links

PubMed source DOI: 10.1136/bmj.1.6064.798-a PMC Full Text

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