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PMID: 7026417 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

The H-Y antigen and its role in natural transplantation.

Human genetics ·Vol. 58 ·No. 1 ·1981-00-00 ·Pages 9-17

Billingham RE, Hings IM

Abstract

A concise overview of the transplantation biology of the H-Y antigen is presented with particular reference to: its prototypic behavior as a weak transplantation antigen; the facility with which mice of certain inbred strains can be rendered tolerant of H-Y incompatible skin grafts; its capacity to instigate graft-versus-host reactions; its significance in clinical transplantation; and finally, H-2 control of anti-H-Y immune responses. The role of the H-Y antigen in natural transplantation, i.e. pregnancy, is then reviewed. Evidence is presented to support the hypothesis that in certain cases maternal immune responses directed specifically to the H-Y antigen can exert selective pressures on male zygotes, producing deviant sex ratios in certain experimental and clinical situations.

MeSH Terms
Animals Female Graft Rejection Graft vs Host Reaction H-2 Antigens/immunology H-Y Antigen/genetics,immunology Histocompatibility Antigens Class II/immunology Humans Immune Tolerance Immunization Male Mice Mice, Inbred C57BL Mice, Inbred DBA Pregnancy Sex Differentiation Sex Ratio Skin Transplantation Spleen/immunology Y Chromosome
Chemicals
H-2 Antigens H-Y Antigen Histocompatibility Antigens Class II
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Billingham R E
Hings I M
References (60)
60 references, click to expand
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00284141
Published
1981-00-00
Pages
9-17
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
Grants
NIAID NIH HHS · AI 10678 · United States
External Links
PubMed source DOI: 10.1007/BF00284141 View journal details
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