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PMID: 7017147 Published · ppublish English Journal Article Review

Localisation of male determining factors in man: a thorough review of structural anomalies of the Y chromosome.

Journal of medical genetics ·Vol. 18 ·No. 3 ·1981-06-00 ·Pages 161-95

Davis RM

Abstract

It is widely accepted that male determination in man depends on the presence of a factor or factors on the Y chromosome. These factors may be localised within the Y chromosome through the study of structural anomalies of the Y. A thorough review of seven different structural anomalies of the Y is presented: dicentric Y chromosomes, Y isochromosomes, ring Y chromosomes, Y; autosome, Y;X, and Y;Y translocations, and Y deletions. The evidence from these studies indicates that a gene or genes on the short arm or the Y near the centromere play a crucial role in the development of the testes. A few studies indicate that one or more factors on the long arm of the Y may also influence testicular development. If such a factor is present on the long arm, then it too must be very near the centromere. The theory that separate genes independently control the initial development and maturation of the tests (on the long and short arms of the Y, respectively) may be premature. Recently proposed arguments in its favour are examined. Some evidence also indicates the presence of a fertility factor on the non-fluorescent segment of the long arm. Relevant information on the H-Y antigen is discussed.

MeSH Terms
Adolescent Adult Aged Child Child, Preschool Female Humans Infant Infant, Newborn Infertility, Male/genetics Karyotyping Male Middle Aged Oligospermia/genetics Sex Chromosome Aberrations Sex Chromosomes/ultrastructure Sex Determination Analysis Testis/growth & development Turner Syndrome/genetics Y Chromosome/ultrastructure
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Davis R M
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Article Info
Journal
Journal of medical genetics
Abbr.
J Med Genet
ISSN
0022-2593
DOI
10.1136/jmg.18.3.161
Published
1981-06-00
Pages
161-95
Language
English
Region
England
NLM ID
2985087R
PMCID
PMC1048703
Subset
IM
External Links
PubMed source DOI: 10.1136/jmg.18.3.161 PMC Full Text View journal details
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