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PMID: 7016921 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Epinephrine plasma thresholds for lipolytic effects in man: measurements of fatty acid transport with [l-13C]palmitic acid.

The Journal of clinical investigation ·Vol. 67 ·No. 6 ·1981-06-00 ·Pages 1729-38

Galster AD, Clutter WE, Cryer PE, Collins JA, Bier DM

Abstract

To determine the plasma epinephrine thresholds for its lipolytic effect, 60-min epinephrine infusions at nominal rates of 0.1, 0.5, 1.0, 2.5, and 5.0 micrograms/min were performed in each of four normal young adult men while they also received a simultaneous infusion of [1-13C]palmitic acid to estimate inflow transport of plasma free fatty acids. These 20 infusions resulted in steady-state plasma epinephrine concentrations ranging from 12 to 870 pg/ml. Plasma epinephrine thresholds for changes in blood glucose, lactate, and beta-hydroxybutyrate were in the 150--200-pg/ml range reported by us previously (Clutter, W. E., D. M. Bier, S. D. Shah, and P. E. Cryer. 1980. J. Clin. Invest. 66: 94--101.). Increments in plasma glycerol and free fatty acids and in the inflow and outflow transport of palmitate, however, occurred at lower plasma epinephrine thresholds in the range of 75 to 125 pg/ml. Palmitate clearance was unaffected at any steady-state epinephrine level produced. These data indicate that (a) the lipolytic effects of epinephrine occur at plasma levels approximately threefold basal values and (b) lipolysis is more sensitive than glycogenolysis to increments in plasma epinephrine.

MeSH Terms
Adult Biological Transport Blood Glucose Epinephrine/administration & dosage,blood Fatty Acids, Nonesterified/blood,metabolism Glucagon/blood Glycolysis/drug effects Humans Infusions, Parenteral Insulin/blood Lipolysis/drug effects Male Palmitic Acids/administration & dosage
Chemicals
Blood Glucose Fatty Acids, Nonesterified Insulin Palmitic Acids Glucagon Epinephrine
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Galster A D
Clutter W E
Cryer P E
Collins J A
Bier D M
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51 references, click to expand
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/jci110211
Published
1981-06-00
Pages
1729-38
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC370750
Subset
IM
Grants
NIADDK NIH HHS · 1-F32-AM06360 · United States
NIADDK NIH HHS · AM20579 · United States
NICHD NIH HHS · HD 10667 · United States
External Links
PubMed source DOI: 10.1172/jci110211 PMC Full Text View journal details
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