Curing of Escherichia coli K12 plasmids by coumermycin.

Molecular & general genetics : MGG ·Vol. 178 ·No. 1 ·1980-04-00 ·Pages 233-5

Danilevskaya ON, Gragerov AI

Abstract

Low concentrations of the antibiotic coumermycin A1, the inhibitor of bacterial DNA gyrase, effectively eliminate pBR322, pMB9 and other ColE 1 related plasmids from E. coli K12 strains. The curing action of antibiotic seems to result from the plasmid degradation and not just from the inhibition of replication.

MeSH Terms

Aminocoumarins Anti-Bacterial Agents/pharmacology Coumarins/pharmacology DNA, Bacterial/genetics Dose-Response Relationship, Drug Escherichia coli/genetics Plasmids/drug effects Pyrroles/pharmacology

Chemicals

Aminocoumarins Anti-Bacterial Agents Coumarins DNA, Bacterial Pyrroles coumermycin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Danilevskaya O N

Gragerov A I

References (15)

15 references, click to expand

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Proc Natl Acad Sci U S A. 1978 Dec;75(12):5960-3 PMID: 153529
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Proc Natl Acad Sci U S A. 1977 Nov;74(11):4767-71 PMID: 200930
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Proc Natl Acad Sci U S A. 1976 Dec;73(12):4474-8 PMID: 794878
Construction and characterization of new cloning vehicles. II. A multipurpose cloning system.
Gene. 1977;2(2):95-113 PMID: 344137
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Mol Gen Genet. 1979;177(1):169-75 PMID: 231726
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Proc Natl Acad Sci U S A. 1978 Oct;75(10):4838-42 PMID: 368801
Recircularization and autonomous replication of a sheared R-factor DNA segment in Escherichia coli transformants.
Proc Natl Acad Sci U S A. 1973 May;70(5):1293-7 PMID: 4576014
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Article Info

Journal

Molecular & general genetics : MGG

Abbr.

Mol Gen Genet

ISSN

0026-8925

DOI

10.1007/BF00267235

Published

1980-04-00

Pages

233-5

Language

English

Region

Germany

NLM ID

0125036

Subset

External Links

PubMed source DOI: 10.1007/BF00267235

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Curing of Escherichia coli K12 plasmids by coumermycin.

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