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PMID: 6980226 Published · ppublish English Case Reports Journal Article Research Support, U.S. Gov't, P.H.S.

Recurrent pyogenic infections in individuals with absence of the second component of complement.

Journal of clinical immunology ·Vol. 2 ·No. 1 ·1982-01-00 ·Pages 39-45

Sampson HA, Walchner AM, Baker PJ

Abstract

While deficiency of the terminal components of complement (C3-C8) has classically been associated with recurrent pyogenic infections, it has become apparent that C2 deficiency is also associated with recurrent infections in some individuals. The patient presented here had two major pyogenic infections prior to 1 year of age and was found to lack the second component of complement. Studies of alternative complement pathway and humoral and cellular immunity were found to be within normal limits. Family studies suggest an autosomal codominant pattern of inheritance for the C2 defect, which also corresponded to the inheritance of the HLA A10 B18 haplotype. A review of the literature revealed nine other cases of C2-deficient patients with well-documented recurrent infections. In these patients, Streptococcus pneumoniae is the organism most frequently implicated in infectious processes, whether or not their alternative complement pathway is intact.

MeSH Terms
Antibodies, Antinuclear Chemotaxis, Leukocyte Complement Activation Complement C2/analysis,deficiency Female HLA Antigens Hemolysis Humans Immunoglobulin G/biosynthesis Infant Leukocyte Count Neutrophils Pedigree Pneumococcal Infections/immunology Recurrence
Chemicals
Antibodies, Antinuclear Complement C2 HLA Antigens Immunoglobulin G
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sampson H A
Walchner A M
Baker P J
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30 references, click to expand
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Article Info
Journal
Journal of clinical immunology
Abbr.
J Clin Immunol
ISSN
0271-9142
DOI
10.1007/BF00915977
Published
1982-01-00
Pages
39-45
Language
English
Region
Netherlands
NLM ID
8102137
Subset
IM
Grants
NCRR NIH HHS · RR-30 · United States
External Links
PubMed source DOI: 10.1007/BF00915977 View journal details
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