Coated pits act as molecular filters.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 77 ·No. 7 ·1980-07-00 ·Pages 4156-9

Bretscher MS, Thomson JN, Pearse BM

Abstract

Two proteins--theta and H63 antigens--are found to be excluded from coated pits on fibroblast plasma membranes. Coated pits thus act as molecular filters, pinching off, into the cell, lipid vesicles containing a limited number of specific receptors but excluding other plasma membrane proteins. This constitutes part of a lipid flow cycle that was proposed earlier to explain the capping of crosslinked surface antigens.

MeSH Terms

Animals Antigens, Surface Cell Membrane/physiology,ultrastructure Membrane Fluidity Membrane Lipids/metabolism Membrane Proteins/metabolism Mice Molecular Weight T-Lymphocytes/immunology Temperature

Chemicals

Antigens, Surface Membrane Lipids Membrane Proteins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Bretscher M S

Thomson J N

Pearse B M

References (18)

18 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.77.7.4156

Published

1980-07-00

Pages

4156-9

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC349789

Subset

External Links

PubMed source DOI: 10.1073/pnas.77.7.4156 PMC Full Text View journal details

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