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PMID: 6961416 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Chemical identity of the acrasin of the cellular slime mold Polysphondylium violaceum.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 79 ·No. 23 ·1982-12-00 ·Pages 7376-9

Shimomura O, Suthers HL, Bonner JT

Abstract

The aggregation chemoattractant (or acrasin) of Polysphondylium violaceum, a species of cellular slime mold that does not respond chemotactically to cAMP, has been identified. It was extracted and purified from aggregating amoebae, then analyzed for amino acid composition and by IR and mass spectrometry. The active molecule is N-propionyl-gamma-L-glutamyl-L-ornithine-delta-lactam ethyl ester (Mr, 327), which we have named glorin. The compound has been synthesized and shows normal chemotactic activity with the amoebae of P. violaceum.

MeSH Terms
Chemotactic Factors/isolation & purification Chemotaxis Esters Glutamates Myxomycetes/analysis,physiology Ornithine/analogs & derivatives Pterins/isolation & purification
Chemicals
Chemotactic Factors Esters Glutamates Pterins acrasin Ornithine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Shimomura O
Suthers H L
Bonner J T
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20 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.79.23.7376
Published
1982-12-00
Pages
7376-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC347342
Subset
IM
Grants
NIGMS NIH HHS · GM 17856-09 · United States
External Links
PubMed source DOI: 10.1073/pnas.79.23.7376 PMC Full Text View journal details
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