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PMID: 6942413 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Angiotensin alters 45Ca2+ fluxes in bovine adrenal glomerulosa cells.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 78 ·No. 5 ·1981-05-00 ·Pages 3044-8

Elliott ME, Goodfriend TL

Abstract

Angiotensin II stimulated 45Ca2+ release from bovine adrenal glomerulosa cells. It also decreased the influx of 45Ca2+ into glomerulosa cells. The effects were observed within 2 min of hormone addition and were blocked by Saralasin a competitive inhibitor of angiotensin. Des-Phe8-angiotensin II, a biologically inert analog, was inactive in this system. Angiotensin II also inhibited the influx of 133Ba2+ and 54Mn2+, whereas 51Cr6+ and 57Co2+ were unaffected. Alterations in 45Ca2+ fluxes were seen with concentrations of angiotensin that stimulate aldosterone biosynthesis in bovine glomerulosa cell preparations. These results suggest that calcium plays a key role in angiotensin-stimulated aldosteronogenesis.

MeSH Terms
Adrenal Cortex/cytology,drug effects,metabolism Aldosterone/biosynthesis Angiotensin II/pharmacology Animals Biological Transport, Active/drug effects Calcium/metabolism Cattle Kinetics Lanthanum/pharmacology Potassium/pharmacology
Chemicals
Angiotensin II Aldosterone Lanthanum Potassium Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Elliott M E
Goodfriend T L
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42 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.78.5.3044
Published
1981-05-00
Pages
3044-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC319496
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.78.5.3044 PMC Full Text View journal details
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