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PMID: 6938989 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Biosynthesis of vitamin B12: nature of the volatile fragment generated during formation of the corrin ring system.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 78 ·No. 1 ·1981-01-00 ·Pages 11-2

Mombelli L, Nussbaumer C, Weber H, Müller G, Arigoni D

Abstract

It is shown with the help of radiolabeled substrates that biological formation of the corrin ligand system of cobyrinic acid is linked with the release of an equivalent of acetic acid from a hydroporphinoid precursor in which the C-20 atom has undergone methylation prior to its excision from the macrocycle.

MeSH Terms

Acetates/biosynthesis Cell-Free System Chemical Phenomena Chemistry Porphobilinogen/metabolism Propionibacterium/metabolism Vitamin B 12/analogs & derivatives,biosynthesis

Chemicals

Acetates cobyrinic acid Porphobilinogen Vitamin B 12

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Mombelli L

Nussbaumer C

Weber H

Müller G

Arigoni D

References (5)

5 references, click to expand

Ring contraction of hydroporphinoid to corrinoid complexes.
Proc Natl Acad Sci U S A. 1981 Jan;78(1):16-9 PMID: 16592942
Biosynthesis of vitamin B12: mode of incorporation of factor III into cobyrinic acid.
Proc Natl Acad Sci U S A. 1981 Jan;78(1):9-10 PMID: 6938991
Biosynthesis of porphyrins and related macrocycles. Part 10. Vitamin B12: biochemical derivation of cobyrinic acid from uroporphyrinogen III. Studies with corresponding ring c methyl heptacarboxylic prophyrinogen, and proof of seven intact methyl transfers.
J Chem Soc Perkin 1. 1977;2:166-78 PMID: 556735
Biosynthesis of vitamin B12: identity of fragment extruded during ring contraction to the corrin macrocycle.
Proc Natl Acad Sci U S A. 1981 Jan;78(1):13-5 PMID: 6938990
[On the preparation of intermediates in cobyrinic acid biosynthesis by suspensions of Propionibacterium shermanii (author's transl)].
Hoppe Seylers Z Physiol Chem. 1977 Oct;358(10):1315-23 PMID: 924361

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.78.1.11

Published

1981-01-00

Pages

11-2

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC318977

Subset

External Links

PubMed source DOI: 10.1073/pnas.78.1.11 PMC Full Text View journal details

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Biosynthesis of vitamin B12: nature of the volatile fragment generated during formation of the corrin ring system.

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