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PMID: 6938991 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Biosynthesis of vitamin B12: mode of incorporation of factor III into cobyrinic acid.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 78 ·No. 1 ·1981-01-00 ·Pages 9-10

Nussbaumer C, Imfeld M, Wörner G, Müller G, Arigoni D

Abstract

Extensive chemical degradation of cobyrinic acid biosynthesized from a sample of factor III radiochemically labeled in its three methyl groups demonstrates that label is retained exclusively in the two methyl groups at positions C-2 and C-7 and confirms that the C-20 methyl group of the precursor is lost during formation of the corrin ring system.

MeSH Terms
Bacteriochlorophylls/metabolism Chemical Phenomena Chemistry Propionibacterium/metabolism Vitamin B 12/analogs & derivatives,biosynthesis
Chemicals
Bacteriochlorophylls cobyrinic acid Vitamin B 12
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Nussbaumer C
Imfeld M
Wörner G
Müller G
Arigoni D
References (2)
2 references, click to expand
  1. [On cobyrinic acid biosynthesis. Novel methylated hydroporphyrins and their role in cobyrinis acid formation (author's transl)].
    Hoppe Seylers Z Physiol Chem. 1977 Mar;358(3):339-52 PMID: 856710
  2. [On the preparation of intermediates in cobyrinic acid biosynthesis by suspensions of Propionibacterium shermanii (author's transl)].
    Hoppe Seylers Z Physiol Chem. 1977 Oct;358(10):1315-23 PMID: 924361
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.78.1.9
Published
1981-01-00
Pages
9-10
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC318976
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.78.1.9 PMC Full Text View journal details
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