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PMID: 6933559 Published · ppublish English Journal Article

Prolonged survival of bovine adrenal chromaffin cells in rat cerebral ventricles.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 77 ·No. 9 ·1980-09-00 ·Pages 5278-81

Perlow MJ, Kumakura K, Guidotti A

Abstract

Dispersed, cultured bovine adrenal chromaffin cells transplanted into the cerebral ventricles of neonatal and adult rats survived at least 2 mo without evidence of immunological rejection. The cells can be identified by their strong yellow fluorescent reaction with glyoxylic acid, which suggests that they maintain intact the capability of synthesizing and storing catecholamines. The cells did not show sprouting or process formation and appeared to be free in the ventricle or aggregated in clusters. This shows that cells from different animal species and from different tissue origins can be transplanted and can survive in the cerebral ventricles.

MeSH Terms
Adrenal Medulla/cytology Animals Animals, Newborn/immunology Catecholamines/biosynthesis Cattle Cell Survival Cells, Cultured Cerebral Ventricles/immunology Chromaffin System/cytology Graft Survival Microscopy, Fluorescence Rats Time Factors Transplantation, Heterologous
Chemicals
Catecholamines
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Perlow M J
Kumakura K
Guidotti A
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37 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.77.9.5278
Published
1980-09-00
Pages
5278-81
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC350041
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.77.9.5278 PMC Full Text View journal details
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