Home LiteratureArticle Details
PMID: 6837577 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Analysis of active and inactive complement C4 complotypes associated with subtypes of HLA-B17 in different racial groups.

American journal of human genetics ·Vol. 35 ·No. 2 ·1983-03-00 ·Pages 309-17

O'Neill GJ, Nerl C, Pollack MS

Abstract

HLA-A, B, and C antigens and the HLA-linked markers BF, C2, and C4 were determined in 1,799 unrelated Caucasians, 140 North American blacks, 140 Chinese, and 66 Japanese. One allele of the C4A locus (Rodgers), C4A*6, was found to code for a functionally inactive product in HLA-B17 (Bw57)-positive individuals, but for a functionally active product in HLA-B37- or HLA-B27-positive individuals. Further studies revealed that the functionally inactive C4A*6 gene product was found only in one subtype of HLA-B17, namely, 17.1 (Bw57, long). In addition, it was found that the frequency of the other subtype of HLA-B17, namely, 17.2(Bw58, short) varies greatly in different populations and that HLA-Bw58 is associated with either C4A*3,B*1 or C4A*3,B*Q0.

MeSH Terms
Alleles Complement C4/genetics,immunology Gene Frequency Genetic Variation HLA Antigens/genetics Humans Immunoelectrophoresis Phenotype Racial Groups
Chemicals
Complement C4 HLA Antigens
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
O'Neill G J
Nerl C
Pollack M S
References (15)
15 references, click to expand
  1. The HLA system in the Sydney Jewish population.
    Tissue Antigens. 1980 Jan;15(1):94-100 PMID: 12735340
  2. Properdin factor B polymorphism in continental Italy and Sardinia.
    Hum Genet. 1981;58(2):209-12 PMID: 6912819
  3. HL-A antigen, gene, and haplotype frequencies in Denmark.
    Tissue Antigens. 1975 Aug;6(2):70-6 PMID: 1179408
  4. Inherited structural polymorphism in human C2: evidence for genetic linkage between C2 and Bf.
    J Exp Med. 1976 Oct 1;144(4):1111-5 PMID: 978135
  5. The genetic polymorphism of the fourth component of human complement: methodological aspects and a presentation of linkage and association data relevant to its localization in the HLA region.
    J Exp Med. 1977 Nov 1;146(5):1380-9 PMID: 925607
  6. Genetic polymorphism of the fourth component of human complement.
    Vox Sang. 1978;34(5):296-301 PMID: 629046
  7. Chido and Rodgers blood groups are distinct antigenic components of human complement C4.
    Nature. 1978 Jun 22;273(5664):668-70 PMID: 78453
  8. Two HLA-linked loci controlling the fourth component of human complement.
    Proc Natl Acad Sci U S A. 1978 Oct;75(10):5165-9 PMID: 368809
  9. Genetic polymorphism of human complement C4 and detection of heterozygotes.
    Nature. 1979 Nov 8;282(5735):205-7 PMID: 492334
  10. HLA antigens in three common populations in South East Asia--Chinese, Malay and Filipino.
    Tissue Antigens. 1979 May;13(5):361-8 PMID: 91213
  11. Genetic studies of complement C4 in man.
    Hum Genet. 1979;53(1):31-6 PMID: 535900
  12. HLA-A, B, Bf three point association of 1,072 haplotypes in a German population.
    Tissue Antigens. 1979 Oct;14(4):317-24 PMID: 545746
  13. Inherited structural polymorphism of the fourth component of human complement.
    Proc Natl Acad Sci U S A. 1980 Jun;77(6):3576-80 PMID: 6932037
  14. Different HLA antigen associations for the functionally active and inactive products of the complement C4F1 allele.
    Hum Immunol. 1980 Jul;1(1):23-30 PMID: 7263310
  15. Genetic polymorphism in human glycine-rich beta-glycoprotein.
    J Exp Med. 1972 Jan;135(1):68-80 PMID: 4109808
Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1983-03-00
Pages
309-17
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1685544
Subset
IM
Grants
NIAID NIH HHS · AI-19057-01 · United States
NCI NIH HHS · CA-08748 · United States
NCI NIH HHS · CA-22507 · United States
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2