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PMID: 6822420 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Experimental model for dermal granulomatous hypersensitivity in Q fever.

Infection and immunity ·Vol. 39 ·No. 1 ·1983-01-00 ·Pages 388-93

Ascher MS, Berman MA, Parker D, Turk JL

Abstract

Q fever has been associated with granulomatous changes in clinical biopsy material obtained from liver and bone marrow. Local reactions to skin testing have been described in previously sensitized humans, but histological studies of such reactions have not been reported. We note that delayed hypersensitivity reactions to whole-cell phase I Q fever vaccine in immunized guinea pigs have a time course of development of induration characteristic of granulomatous hypersensitivity. Histological examination of such skin reactions on day 9 after testing revealed epithelioid cell infiltration and the presence of large numbers of multinucleated giant cells. Prominent in the sections were fragments of disintegrating polymorphonuclear leukocytes having the appearance of leukocytoclasis. Electron microscopic studies confirmed the presence of epithelioid changes in cells of the mononuclear phagocyte series, as well as extensive collagen deposition. This animal system affords a readily reproducible model of dermal granulomatous hypersensitivity and an opportunity to analyze the immunological basis of this reaction.

MeSH Terms

Animals Disease Models, Animal Female Freund's Adjuvant Granuloma/etiology,pathology Guinea Pigs Hypersensitivity, Delayed/pathology Male Q Fever/immunology,pathology Skin Diseases/etiology,pathology Skin Tests

Chemicals

Freund's Adjuvant

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Ascher M S

Berman M A

Parker D

Turk J L

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25 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.39.1.388-393.1983

Published

1983-01-00

Pages

388-93

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC347951

Subset

External Links

PubMed source DOI: 10.1128/iai.39.1.388-393.1983 PMC Full Text View journal details

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Experimental model for dermal granulomatous hypersensitivity in Q fever.

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