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PMID: 970938 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Preparation of phase 1Q fever antigen suitable for vaccine use.

Applied and environmental microbiology ·Vol. 32 ·No. 1 ·1976-07-00 ·Pages 85-8

Spicer DS, DeSanctis AN

Abstract

Five lots of phase 1 Q fever antigen suitable for use as vaccine were prepared utilizing the Freon-brushite method of antigen purification. Antigen concentration levels were initially adjusted turbidimetrically and later confirmed by antibody response in guinea pigs. Data showed that all lots were essentially identical in purity and antigenicity.

MeSH Terms
Animals Antigens, Bacterial/isolation & purification Bacterial Vaccines Coxiella/immunology Guinea Pigs Humans Methods Q Fever/prevention & control
Chemicals
Antigens, Bacterial Bacterial Vaccines
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Spicer D S
DeSanctis A N
References (10)
10 references, click to expand
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    Stain Technol. 1964 May;39:135-40 PMID: 14157454
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    Proc Soc Exp Biol Med. 1970 Dec;135(3):706-8 PMID: 5486704
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    Am J Hyg. 1951 May;53(3):326-31 PMID: 14829444
  7. A microagglutination technique for detection and measurement of rickettsial antibodies.
    Acta Virol. 1969 Jan;13(1):60-6 PMID: 4387631
  8. Preparation of purified suspensions of Coxiella burneti by Genetron extraction followed by continuous-flow ultracentrifugation.
    Appl Microbiol. 1972 May;23(5):841-5 PMID: 4555634
  9. Purification of large quantities of coxiella burnetii rickettsia by density gradient zonal centrifugation.
    Appl Microbiol. 1972 May;23(5):1015-22 PMID: 5031557
  10. Intradermal sensitivity testing in man with a purified vaccine for Q fever.
    Am J Public Health Nations Health. 1962 Jan;52:87-93 PMID: 14461400
Article Info
Journal
Applied and environmental microbiology
Abbr.
Appl Environ Microbiol
ISSN
0099-2240
DOI
10.1128/aem.32.1.85-88.1976
Published
1976-07-00
Pages
85-8
Language
English
Region
United States
NLM ID
7605801
PMCID
PMC170010
Subset
IM
External Links
PubMed source DOI: 10.1128/aem.32.1.85-88.1976 PMC Full Text View journal details
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