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PMID: 6818955 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Inhibition of phosphatidylcholine synthesis by vasopressin and angiotensin in rat hepatocytes.

The Biochemical journal ·Vol. 208 ·No. 2 ·1982-11-15 ·Pages 453-7

Alemany S, Varela I, Mato JM

Abstract

The addition of 1 microM-vasopressin or -angiotensin to isolated rat hepatocytes induced a fast transient inhibition of the rate of incorporation of [Me-3H]choline into phosphatidylcholine. The cationophore A23187 induced a similar inhibition of phosphatidylcholine synthesis. The addition of micromolar Ca2+ to rat liver microsomes inhibited the activity of CDP-choline: 1,2-diacylglycerol cholinephosphotransferase. This inhibition is due a decrease in the Vmax. of the enzyme without affecting the Km for CDP-choline. It is concluded that Ca2+ regulates phosphatidylcholine synthesis in rat liver.

MeSH Terms
Angiotensin II/pharmacology Animals Calcimycin/pharmacology Calcium/pharmacology Choline/metabolism Depression, Chemical In Vitro Techniques Kinetics Liver/cytology,drug effects,metabolism Phosphatidylcholines/biosynthesis Rats Rats, Inbred Strains Vasopressins/pharmacology
Chemicals
Phosphatidylcholines Vasopressins Angiotensin II Calcimycin Choline Calcium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Alemany S
Varela I
Mato J M
References (19)
19 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj2080453
Published
1982-11-15
Pages
453-7
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1153983
Subset
IM
External Links
PubMed source DOI: 10.1042/bj2080453 PMC Full Text View journal details
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