Mechanism for selectively inhibiting the activation of cyclic nucleotide phosphodiesterase and adenylate cyclase by antipsychotic agents.

Adenylyl Cyclase Inhibitors Animals Antipsychotic Agents/metabolism,pharmacology Binding Sites Brain/enzymology Calcium/physiology Carrier Proteins/metabolism Enzyme Activation/drug effects Hydrogen-Ion Concentration In Vitro Techniques Isoenzymes/antagonists & inhibitors Kinetics Nucleotides, Cyclic Phosphodiesterase Inhibitors Rats Receptors, Dopamine/physiology

Adenylyl Cyclase Inhibitors Antipsychotic Agents Carrier Proteins Isoenzymes Nucleotides, Cyclic Phosphodiesterase Inhibitors Receptors, Dopamine Calcium