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PMID: 6801183 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Role of the thymus in directing the development of a subset of B lymphocytes.

The Journal of experimental medicine ·Vol. 155 ·No. 3 ·1982-03-01 ·Pages 924-36

Mond JJ, Scher I, Cossman J, Kessler S, Mongini PK, Hansen C, Finkelman FD, Paul WE

Abstract

In an effort to evaluate the role of the thymus in influencing the development of Lyb-5- B lymphocytes, mice expressing both the xid and nu gene defects were studied. Mice expressing either of these defects respond to both trinitrophenylated Brucellus abortus and lipopolysaccharide; whereas mice with the combined defect show markedly suppressed responses. The other abnormalities included: (a) greater than 80 percent diminution of serum Ig levels; (b) significant increase in the number of sIgM+ sIgD- B lymphocytes; (c) reduced expression of IgD on sIgD+ cells; and (d) a strikingly abnormal histology of their lymphoid tissue. Because nu/nu mice that do not express the xid defect appear relatively normal, it would suggest that the development of Lyb-5- B lymphocytes require a thymic influence for normal maturation, whereas, Lyb-5+ B lymphocytes are relatively independent of such influences.

MeSH Terms
Animals Antibody-Producing Cells/cytology Antigens, Bacterial/immunology B-Lymphocytes/classification,cytology Brucella abortus/immunology Immunoglobulin G/biosynthesis Immunoglobulin M/biosynthesis Lipopolysaccharides/pharmacology Lymph Nodes/pathology Lymphocyte Activation Mice Mice, Inbred CBA Mice, Nude/genetics Receptors, Antigen, B-Cell/analysis,biosynthesis Thymus Gland/immunology Trinitrobenzenes/immunology
Chemicals
Antigens, Bacterial Immunoglobulin G Immunoglobulin M Lipopolysaccharides Receptors, Antigen, B-Cell Trinitrobenzenes
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Mond J J
Scher I
Cossman J
Kessler S
Mongini P K
Hansen C
Finkelman F D
Paul W E
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.155.3.924
Published
1982-03-01
Pages
924-36
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2186612
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.155.3.924 PMC Full Text View journal details
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