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PMID: 4403476 Published · ppublish English Journal Article

Genetic control of the antibody response to type 3 pneumococcal polysaccharide in mice. I. Evidence that an X-linked gene plays a decisive role in determining responsiveness.

The Journal of experimental medicine ·Vol. 136 ·No. 4 ·1972-10-01 ·Pages 931-49

Amsbaugh DF, Hansen CT, Prescott B, Stashak PW, Barthold DR, Baker PJ

Abstract

The IgM antibody response to Type III pneumococcal polysaccharide (SSS-III) was assessed in F(1), F(2), and backcross progeny derived from high (BALB/cAnN) and extremely low (CBA/HN) responding parental strains of inbred mice. The results of these studies indicated that a major component involved in the antibody response is X-linked, i.e., carried on the X chromosome; this component determines responsiveness to SSS-III in an almost quantal or "all-or-none" manner. Other factors, presumably autosomal genes, regulate the magnitude of the antibody response produced by mice possessing the X-linked gene; these appear to influence independently the number of antibody-producing cells found after immunization and the amount of antibody made by such cells. Strains of inbred mice varied widely in their ability to respond to SSS-III. Responsiveness was not associated with H-2 histocompatibility type. The implications of these findings with respect to the genetic control of the antibody response to SSS-III are discussed.

MeSH Terms
Animals Antibodies/analysis Antibody Formation Antibody-Producing Cells Antigens, Bacterial Crosses, Genetic Erythrocytes/immunology Escherichia coli/immunology Female Hemolytic Plaque Technique Immunogenetics Immunoglobulin M/analysis Male Mice Mice, Inbred Strains Polysaccharides, Bacterial Sex Chromosomes Sheep/immunology Streptococcus pneumoniae/immunology
Chemicals
Antibodies Antigens, Bacterial Immunoglobulin M Polysaccharides, Bacterial
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Amsbaugh D F
Hansen C T
Prescott B
Stashak P W
Barthold D R
Baker P J
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.136.4.931
Published
1972-10-01
Pages
931-49
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2139279
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.136.4.931 PMC Full Text View journal details
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