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PMID: 6788413 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Anti-spectrin in sera containing smooth muscle autoantibodies from patients with chronic active hepatitis.

Clinical and experimental immunology ·Vol. 43 ·No. 1 ·1981-01-00 ·Pages 87-93

Garbarz M, Dhermy D, Bournier O, Bezeaud A, Boivin P

Abstract

Sera from patients with chronic active hepatitis containing anti-smooth muscle autoantibodies (SMA) react against rabbit muscle actin as well as human red cell spectrin. These anti-spectrin antibodies recognize the same antigen as rabbit anti-human spectrin antibodies and are not involved in the staining pattern given by SMA-containing sera tested with smooth muscle sections. These anti-spectrin antibodies probably recognize an antigenic structure common to both spectrin and another as yet undetermined molecule (which however is not likely to be myosin).

MeSH Terms
Actins/immunology Autoantibodies/analysis Chronic Disease Electrophoresis, Polyacrylamide Gel Hepatitis/immunology Humans Immunodiffusion Membrane Proteins/immunology Muscle, Smooth/immunology Spectrin/immunology
Chemicals
Actins Autoantibodies Membrane Proteins Spectrin
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Garbarz M
Dhermy D
Bournier O
Bezeaud A
Boivin P
References (18)
18 references, click to expand
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
Published
1981-01-00
Pages
87-93
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1537121
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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