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PMID: 6754947 Published · ppublish English Journal Article Review

Epithelial cell volume modulation and regulation.

The Journal of membrane biology ·Vol. 69 ·No. 3 ·1982-00-00 ·Pages 167-76

Spring KR, Ericson AC

Abstract

Epithelial cell volume is a sensitive indicator of the balance between solute entry into the cell and solute exit. Solute accumulation in the cell leads to cell swelling because the water permeability of the cell membranes is high. Similarly, solute depletion leads to cell shrinkage. The rate of volume change under a variety of experimental conditions may be utilized to study the rate and direction of solute transport by an epithelial cell. The pathways of water movement across an epithelium may also be deduced from the changes in cellular volume. A technique for the measurement of the volume of living epithelial cells is described, and a number of experiments are discussed in which cell volume determination provided significant new information about the dynamic behavior of epithelia. The mechanism of volume regulation of epithelial cells exposed to anisotonic bathing solution is discussed and shown to involve the transient stimulation of normally dormant ion exchangers in the cell membrane.

MeSH Terms
Animals Biological Transport, Active Body Water/metabolism Cell Membrane/physiology Epithelial Cells Epithelium/physiology Gallbladder/cytology,physiology Necturus Sodium Chloride/metabolism
Chemicals
Sodium Chloride
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Spring K R
Ericson A C
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62 references, click to expand
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Article Info
Journal
The Journal of membrane biology
Abbr.
J Membr Biol
ISSN
0022-2631
DOI
10.1007/BF01870396
Published
1982-00-00
Pages
167-76
Language
English
Region
United States
NLM ID
0211301
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01870396 View journal details
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