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PMID: 6714225 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Altered globin gene transcription pattern and the presence of a 7-8 kb alpha A globin gene transcript in avian erythroblastosis virus-transformed cells.

The EMBO journal ·Vol. 3 ·No. 3 ·1984-03-00 ·Pages 491-5

Therwath A, Mengod G, Scherrer K

Abstract

Immature chick erythroid cells transformed by avian erythroblastosis virus (AEV) display an altered pattern of globin gene transcription leading to the abortive phenotypic expression of such transcripts. Detectable adult globin gene-specific RNA sequences, confined exclusively to the nucleus, are uniquely of the alpha A type. The alpha A globin-specific sequences occur in transcripts 7-8 kb long from which the 5' contiguous alpha D gene product is absent, and also in fragments smaller than 9S globin mRNA. The implication of this observation for schemes of post-transcriptional regulation of gene expression and viral transformation are discussed.

MeSH Terms
Alpharetrovirus Animals Cell Transformation, Viral Chickens Gene Expression Regulation Globins/genetics Molecular Weight Nucleic Acid Precursors/genetics RNA Processing, Post-Transcriptional RNA, Messenger/genetics Transcription, Genetic
Chemicals
Nucleic Acid Precursors RNA, Messenger Globins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Therwath A
Mengod G
Scherrer K
References (24)
24 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1984-03-00
Pages
491-5
Language
English
Region
England
NLM ID
8208664
PMCID
PMC557375
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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