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PMID: 6628589 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Neuronal proliferation in the 9-month-old rodent-radioautographic study of granule cells in the hippocampus.

Experimental brain research ·Vol. 52 ·No. 1 ·1983-00-00 ·Pages 1-5

Kaplan MS, Bell DH

Abstract

Nine-month-old rats were injected with 5 microCi 3H-thymidine (3H-Tdr) and allowed to survive for 20 days. In light-microscopic radioautographs, labeled cells were found in the granule cell layer of the hippocampus. Analysis of electron micrographs of the labeled cells, taken from re-embedded 1.5 micron radioautographic sections, clearly demonstrated their neuronal nature with synapses along their cell bodies and dendrites. Our results indicate that 0.025% of the granule neurons are heavily labeled in the dorsal hippocampus. Electron microscopy of re-embedded light-microscopic radioautographic sections confirms that granule neurons in the rodent are newly formed up until 9 months after birth.

MeSH Terms
Aging Animals Autoradiography Cell Division Granulocytes/physiology,ultrastructure Hippocampus/cytology Male Neurons/physiology Rats/physiology Rats, Inbred Strains Thymidine Tritium
Chemicals
Tritium Thymidine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kaplan M S
Bell D H
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26 references, click to expand
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Article Info
Journal
Experimental brain research
Abbr.
Exp Brain Res
ISSN
0014-4819
DOI
10.1007/BF00237141
Published
1983-00-00
Pages
1-5
Language
English
Region
Germany
NLM ID
0043312
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00237141 View journal details
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