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PMID: 6620324 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Genetic linkage between Becker muscular dystrophy and a polymorphic DNA sequence on the short arm of the X chromosome.

Journal of medical genetics ·Vol. 20 ·No. 4 ·1983-08-00 ·Pages 255-8

Kingston HM, Thomas NS, Pearson PL, Sarfarazi M, Harper PS

Abstract

A study of DNA restriction fragment polymorphisms and Becker muscular dystrophy has shown eight families informative for the cloned sequence L1.28, which is located on the short arm of the X chromosome between Xp110 and Xp113. Analysis of these families reveals linkage between the two loci, with the maximum likelihood estimate of the genetic distance being 16 centiMorgans (95% confidence limits between 7 and 32 centiMorgans). Since a study of DNA polymorphisms in Duchenne muscular dystrophy has shown a comparable linkage distance with L1.28, our results suggest that the locus for Becker muscular dystrophy, like that for Duchenne dystrophy, is on the short arm of the X chromosome, and further that these two loci may be closely linked or possibly allelic.

MeSH Terms
DNA/genetics Female Genes, Recessive Genetic Linkage Humans Male Muscular Dystrophies/genetics Pedigree Polymorphism, Genetic X Chromosome
Chemicals
DNA
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Kingston H M
Thomas N S
Pearson P L
Sarfarazi M
Harper P S
References (18)
18 references, click to expand
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Article Info
Journal
Journal of medical genetics
Abbr.
J Med Genet
ISSN
0022-2593
DOI
10.1136/jmg.20.4.255
Published
1983-08-00
Pages
255-8
Language
English
Region
England
NLM ID
2985087R
PMCID
PMC1049115
Subset
IM
External Links
PubMed source DOI: 10.1136/jmg.20.4.255 PMC Full Text View journal details
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