Home LiteratureArticle Details
PMID: 6616442 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Tumor heterogeneity: biological implications and therapeutic consequences.

Cancer metastasis reviews ·Vol. 2 ·No. 1 ·1983-00-00 ·Pages 5-23

Heppner GH, Miller BE

Abstract

暂无摘要

MeSH Terms
Animals Cell Communication Cell Division Humans Neoplasms/pathology,therapy Neoplasms, Experimental/pathology,therapy
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Heppner G H
Miller B E
References (169)
169 references, click to expand
  1. Characterization of tumor lines derived from spontaneous metastases of a transplanted murine sarcoma.
    Eur J Cancer. 1981 Jan;17(1):71-6 PMID: 7262148
  2. Differential tumor immunogenicity of L1210 and its sublines. I. Effect of an increased antigen density on tumor cell surfaces on primary B cell responses in vitro.
    J Immunol. 1977 Sep;119(3):983-6 PMID: 330761
  3. Arrest and metastasis of blood-borne tumor cells are modified by fusion of plasma membrane vesicles from highly metastatic cells.
    Proc Natl Acad Sci U S A. 1980 Jan;77(1):399-403 PMID: 6928631
  4. Is somatic mutation the major mechanism of malignant transformation?
    J Natl Cancer Inst. 1980 May;64(5):995-1000 PMID: 6929024
  5. Generation of fibroblast-like cells from cloned epithelial mammary cells in vitro: a possible new cell type.
    Proc Natl Acad Sci U S A. 1981 Apr;78(4):2345-9 PMID: 6166007
  6. Phenotypic variance among cells isolated from spontaneous mouse mammary tumors in primary suspension culture.
    Cancer Res. 1981 Mar;41(3):1154-64 PMID: 7459857
  7. Heterologous and homologous growth of transplants during the course of development of spontaneous mammary tumors in C3H mice.
    J Natl Cancer Inst. 1948 Mar;8(4):173-89 PMID: 18856411
  8. Interactions between tumor subpopulations affecting their sensitivity to the antineoplastic agents cyclophosphamide and methotrexate.
    Cancer Res. 1981 Nov;41(11 Pt 1):4378-81 PMID: 7306965
  9. Heterogeneity of beta 2-microglobulin in human breast carcinoma.
    Lab Invest. 1981 Jul;45(1):46-57 PMID: 6166789
  10. Effects of oxygen radical scavengers and antioxidants on phagocyte-induced mutagenesis.
    J Immunol. 1982 Jun;128(6):2770-2 PMID: 6804566
  11. Characterization of primary hepatocellular carcinomas and initial transplant generations.
    Cancer Res. 1973 Dec;33(12):3330-8 PMID: 4357361
  12. Differential localization of human pancreas cancer-associated antigen and carcinoembryonic antigen in homologous pancreatic tumoral xenograft.
    J Natl Cancer Inst. 1981 Sep;67(3):563-9 PMID: 6944528
  13. Variable content of histaminase, L-dopa decarboxylase and calcitonin in small-cell carcinoma of the lung. Biologic and clinical implications.
    N Engl J Med. 1978 Jul 20;299(3):105-10 PMID: 26872
  14. An unusual bronchial carcinoid tumor: light and electron microscopy.
    Hum Pathol. 1981 Apr;12(4):338-48 PMID: 6263786
  15. Differential response by human melanoma cells to 1,3-bis-(2-chloroethyl)-1-nitrosourea and bleomycin.
    Mutat Res. 1973 Aug;19(2):277-80 PMID: 4127142
  16. Population changes of a rat leukemia by different routes of transplantation.
    J Natl Cancer Inst. 1974 Sep;53(3):773-81 PMID: 4528680
  17. Heterogeneity of expression and induction of mouse mammary tumor virus antigens in mouse mammary tumors.
    Cancer Res. 1982 Nov;42(11):4325-9 PMID: 6290031
  18. Cell clones with different sensitivity to cytostatic drugs in methylcholanthrene-induced mouse sarcomas.
    Acta Pathol Microbiol Scand A. 1974 Jan;82(1):41-7 PMID: 4827350
  19. A comparison of the migration patterns of normal and malignant cells in two assay systems.
    Am J Pathol. 1978 Jan;90(1):159-72 PMID: 619691
  20. Tumorigenicity of human malignant melanocytes in nude mice in relation to their differentiation in vitro.
    J Natl Cancer Inst. 1980 May;64(5):1029-40 PMID: 6929009
  21. A possible mammary stem cell line.
    Cell. 1978 Sep;15(1):283-98 PMID: 699048
  22. Proceedings: Interactions of separate types of cells during normal and neoplastic mammary gland growth.
    J Invest Dermatol. 1974 Jul;63(1):24-47 PMID: 4365989
  23. Endomitotic reduplication mechanisms in ascites tumors of the mouse.
    J Natl Cancer Inst. 1953 Aug;14(1):1-43 PMID: 13097135
  24. The chromosomes of fifty primary Rous rat sarcomas.
    Hereditas. 1971;69(2):155-86 PMID: 4376138
  25. Inherent changes in the in vivo growth characteristics of C3H/He mammary carcinomas.
    Cancer Res. 1980 Oct;40(10):3495-3501 PMID: 7438036
  26. Conversion of solid neoplasms into ascites tumors.
    Ann N Y Acad Sci. 1956 Mar 14;63(5):640-61 PMID: 13314425
  27. Phenotypic drift of metastatic and cell-surface properties of mammary adenocarcinoma cell clones during growth in vitro.
    Int J Cancer. 1981 Dec;28(6):731-8 PMID: 7037655
  28. Increasing metastatic potential is associated with increasing genetic instability of clones isolated from murine neoplasms.
    Proc Natl Acad Sci U S A. 1981 Nov;78(11):6949-52 PMID: 6947269
  29. Cell-cycle dependent appearance of murine leukemia-sarcoma virus antigens.
    J Virol. 1974 Jun;13(6):1169-75 PMID: 4134044
  30. Proliferation-dependent cytotoxicity of anticancer agents: a review.
    Cancer Res. 1975 Oct;35(10):2619-30 PMID: 1098765
  31. Heterogeneity and variability of artificial lung colony-forming ability among clones from mouse fibrosarcoma.
    Cancer Res. 1978 Oct;38(10):3349-51 PMID: 688224
  32. REGULATION OF GROWTH AND ORIENTATION IN HAMSTER CELLS TRANSFORMED BY POLYOMA VIRUS.
    Virology. 1964 Oct;24:165-74 PMID: 14240384
  33. RELATIONSHIP BETWEEN GROWTH RATE AND DIFFERENTIATION OF MELANOMA IN VIVO.
    J Natl Cancer Inst. 1964 Jun;32:1201-10 PMID: 14191394
  34. Heterogeneous response of disseminated human ovarian cancers to cytostatics in vitro.
    Acta Obstet Gynecol Scand. 1979;58(6):543-6 PMID: 550694
  35. Cytologic uniformity of breast cancer from different localizations: a pattern analysis study.
    Exp Cell Biol. 1979;47(4):241-9 PMID: 223894
  36. Growth factors from murine sarcoma virus-transformed cells.
    Proc Natl Acad Sci U S A. 1978 Aug;75(8):4001-5 PMID: 211512
  37. The plating of tumor components on the subcutaneous expanses of young mice. Findings with benign and malignant epidermal growths and with mammary carcinomas.
    J Exp Med. 1962 Jun 1;115:1211-30 PMID: 13906401
  38. Clonal origin of human tumors.
    Annu Rev Med. 1979;30:135-43 PMID: 400484
  39. Outgrowth of grafts containing different ratios of hormone-dependent and independent mouse mammary tumor cells.
    Cancer Lett. 1981 Jun;13(1):71-7 PMID: 7306946
  40. Therapy of mouse lymphoma with monoclonal antibodies to glycolipid: selection of low antigenic variants in vivo.
    Science. 1981 Jan 30;211(4481):487-9 PMID: 7455688
  41. In vivo isolation of a metastatic tumor cell variant involving selective and nonadaptive processes.
    J Natl Cancer Inst. 1981 Jan;66(1):183-9 PMID: 6935459
  42. Inhibition of subcutaneously growing line 1 carcinomas due to metastatic spread.
    Cancer Res. 1974 Aug;34(8):2005-10 PMID: 4366938
  43. Alteration of the survival response of two human colon carcinoma subpopulations to x-irradiation by N,N-dimethylformamide.
    Cancer Res. 1982 Jan;42(1):30-4 PMID: 7053856
  44. Tumor shedding and coagulation.
    Science. 1981 May 22;212(4497):923-4 PMID: 7195067
  45. The variability of estrogen receptors in metastatic breast cancer.
    Am J Surg. 1979 Feb;137(2):260-2 PMID: 426187
  46. Methods of conditioning the graft in tumor transplantation.
    J Natl Cancer Inst. 1953 Dec;14(3):723-39; discussion, 741-3 PMID: 13233824
  47. Clonal heterogeneity of small-cell anaplastic carcinoma of the lung demonstrated by flow-cytometric DNA analysis.
    Cancer Res. 1980 Nov;40(11):4295-300 PMID: 6258777
  48. Free tumor cell growth in the peritoneal cavity (ascites tumor) of mice bearing subcutaneous tumors.
    Cancer Res. 1956 Jul;16(6):553-8 PMID: 13343129
  49. The prognostic and biological significance of cellular heterogeneity in medullary thyroid carcinoma: a study of calcitonin, L-dopa decarboxylase, and histaminase.
    J Clin Endocrinol Metab. 1982 Feb;54(2):233-40 PMID: 6798062
  50. Preliminary report on the efficacy of sequential methotrexate and 5-fluorouracil in advanced breast cancer.
    Cancer. 1981 Jun 1;47(11):2552-5 PMID: 7020915
  51. Natural polyclonality of spontaneous AKR leukemia and its consequences for so-called specific immunotherapy.
    J Natl Cancer Inst. 1979 Mar;62(3):623-7 PMID: 84093
  52. On the presence within tumours of clones that differ in sensitivity to cytostatic drugs.
    Acta Pathol Microbiol Scand A. 1974 Jan;82(1):35-40 PMID: 4827349
  53. The effect of multiple tumours on mammary tumour growth rates in the C3H mouse.
    Br J Cancer. 1970 Sep;24(3):542-7 PMID: 5475756
  54. Effect of methotrexate and 1-beta-D-arabinofuranosylcytosine on pools of deoxyribonucleoside triphosphates in L1210 ascites cells.
    Cancer Res. 1981 Feb;41(2):505-10 PMID: 7448798
  55. Sex hormone receptors in mammary tumours of GR mice.
    Nature. 1976 Sep 30;263(5576):386-9 PMID: 987544
  56. Adaptation versus selection as the mechanism responsible for the relapse of prostatic cancer to androgen ablation therapy as studied in the Dunning R-3327-H adenocarcinoma.
    Cancer Res. 1981 Dec;41(12 Pt 1):5070-5 PMID: 7307008
  57. Growth of a local tumor exerts a specific inhibitory effect on progression of lung metastases.
    Int J Cancer. 1978 May 15;21(5):617-25 PMID: 659027
  58. Synergistic effect of ricin in combination with daunorubicin, cis-dichlorodiammineplatinum(II) and vincristine in systemic L1210 leukemia.
    Cancer Res. 1982 Jun;42(6):2152-8 PMID: 7200398
  59. Experimental chemotherapy of human tumors heterotransplanted in nude mice.
    Antibiot Chemother (1971). 1980;28:21-7 PMID: 6998362
  60. A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate.
    Cancer Treat Rep. 1979 Nov-Dec;63(11-12):1727-33 PMID: 526911
  61. Further evidence favoring the concept of the stem cell in ascites tumors of rats.
    Ann N Y Acad Sci. 1956 Mar 14;63(5):818-30 PMID: 13314436
  62. Noncycling tumor cells are sensitive targets for the antiproliferative activity of human interferon.
    Science. 1979 Nov 30;206(4422):1091-3 PMID: 493995
  63. Selective modification of the X ray survival response of two mouse mammary adenocarcinoma sublines by N,N-dimethylformamide.
    Int J Radiat Oncol Biol Phys. 1981 Jul;7(7):943-7 PMID: 7309591
  64. Structural alterations in the surface membrane during the cell cycle.
    J Cell Biol. 1971 Aug;50(2):562-4 PMID: 4107022
  65. Cancer invasion and metastasis.
    Q Rev Biol. 1980 Jun;55(2):121-42 PMID: 6251508
  66. Comparison of the metastatic properties of B16 melanoma clones isolated from cultured cell lines, subcutaneous tumors, and individual lung metastases.
    Cancer Res. 1982 Jul;42(7):2770-8 PMID: 7083167
  67. Isolation, karyotype, and clonal growth of heterogeneous subpopulations of human malignant gliomas.
    Cancer Res. 1981 Jun;41(6):2349-59 PMID: 7016313
  68. Mutation caused by human phagocytes.
    Science. 1981 May 1;212(4494):546-7 PMID: 6259738
  69. Heterogeneity in drug sensitivity among tumor cell subpopulations of a single mammary tumor.
    Cancer Res. 1978 Nov;38(11 Pt 1):3758-63 PMID: 698935
  70. The inhibitory influence of a transplanted hamster lymphoma on metastasis.
    Cancer Res. 1960 Aug;20:1094-100 PMID: 13851590
  71. Immunofluorescent detection of estrogen receptors in breast cancer. Comparison with dextran-coated charcoal and sucrose gradient assays.
    Cancer. 1978 Mar;41(3):907-11 PMID: 346191
  72. Hemopoietic stem cell differentiation.
    Biochim Biophys Acta. 1980 Nov 26;605(4):431-59 PMID: 7006701
  73. Mixed tumor challenge of strain specific and nonspecific TA3 mouse ascites mammary adenocarcinoma.
    Int Arch Allergy Appl Immunol. 1973;44(3):434-40 PMID: 4708778
  74. Collagenolytic activity of rabbit V2-carcinoma growing at multiple sites.
    Biochem Biophys Res Commun. 1978 Jan 13;80(1):33-8 PMID: 203284
  75. Development and characterization of mouse hyperplastic mammary outgrowth lines from BALB/cfC3H hyperplastic alveolar nodules.
    Cancer Res. 1980 Nov;40(11):4232-42 PMID: 6258774
  76. Cytochemical study of estrogen receptor in human mammary cancer.
    Am J Clin Pathol. 1978 Aug;70(2):197-203 PMID: 80958
  77. Differential sensitivites of human melanoma cells grown in vitro to arabinosylcytosine.
    Cancer Res. 1972 Dec;32(12):2733-6 PMID: 4644205
  78. Immunological resistance to pulmonary metastases in C3Hf-Bu mice bearing syngeneic fibrosarcoma of different sizes.
    Cancer Res. 1974 Jan;34(1):61-71 PMID: 4809463
  79. Isolation of a cellular subpopulation from a human colonic carcinoma cell line.
    Cancer Res. 1980 May;40(5):1574-9 PMID: 6445228
  80. HL-A expression on the G1, S, and G2 cell-cycle stages of human lymphoid cells.
    J Natl Cancer Inst. 1974 Oct;53(4):913-20 PMID: 4139277
  81. Intratumor immunologic heterogeneity.
    Cancer Metastasis Rev. 1982;1(4):319-34 PMID: 6192904
  82. Malignant potential of murine stromal cells after transplantation of human tumors into nude mice.
    Science. 1981 Apr 3;212(4490):65-7 PMID: 7209521
  83. The DNA content of tumor cells. 1. Polyps and adenocarcinomas of the intestine of man.
    J Natl Cancer Inst. 1960 Feb;24:471-82 PMID: 13834643
  84. Immunocytochemical distribution of mouse mammary tumor virus antigens in BALB/cfC3H mammary epithelium.
    J Natl Cancer Inst. 1979 Sep;63(3):813-20 PMID: 224238
  85. Antigenic differences among osteogenic sarcoma tumor cells taken from different locations in human tumors.
    Cancer Res. 1977 Sep;37(9):3173-83 PMID: 69491
  86. Enhancement of the tumorigenicity of preneoplastic mammary nodule lines by enzymatic dissociation.
    J Natl Cancer Inst. 1978 May;60(5):1121-6 PMID: 205661
  87. Quantitative studies of antigen expression in cultured murine lymphoma cells. I. Cell-surface antigens in "Asynchronous" cultures.
    J Natl Cancer Inst. 1972 Dec;49(6):1599-606 PMID: 4647845
  88. Influence of serial transplantation on the immunological-clinical correlates of BALB/cfC3H mouse mammary tumors.
    Cancer Res. 1978 Aug;38(8):2492-500 PMID: 667845
  89. Cytotoxic and cytokinetic effects of thymidine, 5-fluorouracil, and deoxycytidine on HeLa cells in culture.
    Cancer Res. 1981 Jul;41(7):2627-32 PMID: 7248935
  90. On heterogeneity of non-Hodgkin's lymphomas as regards sensitivity to cytostatic drugs. An in vitro study.
    Eur J Cancer. 1980 May;16(5):647-54 PMID: 7389791
  91. Characterization of high- and low-metastatic clones derived from a methylcholanthrene-induced murine fibrosarcoma.
    Cancer Res. 1982 Mar;42(3):1046-51 PMID: 6174210
  92. Metastatic heterogeneity of cells from an ultraviolet light-induced murine fibrosarcoma of recent origin.
    Cancer Res. 1978 Sep;38(9):2962-7 PMID: 679204
  93. Generation of highly metastatic tumors in DBA/2 mice. Oncogenicity of a strain tumor cells.
    Invasion Metastasis. 1981;1(1):22-33 PMID: 7188380
  94. Tumor heterogeneity and stability of the metastatic phenotype of mouse KHT sarcoma cells.
    Cancer Res. 1981 Apr;41(4):1368-72 PMID: 7214323
  95. Phenotypic diversity as an early property of putative preneoplastic hepatocyte populations in liver carcinogenesis.
    Cancer Res. 1980 Mar;40(3):725-33 PMID: 6110477
  96. Heterogeneity of tumor cells from a single mouse mammary tumor.
    Cancer Res. 1978 Oct;38(10):3174-81 PMID: 210930
  97. Heterogeneity in surface antigen and glycoprotein expression of cell lines derived from different melanoma metastases of the same patient. Implications for the study of tumor antigens.
    J Exp Med. 1981 Dec 1;154(6):1764-78 PMID: 6976407
  98. Junctional intercellular communication and the control of growth.
    Biochim Biophys Acta. 1979 Feb 4;560(1):1-65 PMID: 216404
  99. Carcinogenicity of tumor cell populations: origin of a putative H-2 isoantigenic loss variant tumor.
    J Natl Cancer Inst. 1980 May;64(5):1221-30 PMID: 6929020
  100. Different metastatic potential of in vitro and in vivo lines selected from Lewis lung carcinoma: correlation with response to different bleomycin schedulings.
    Invasion Metastasis. 1981;1(4):227-38 PMID: 6203864
  101. The generation of tumor heterogeneity in vivo.
    Int J Cancer. 1980 Feb 15;25(2):261-5 PMID: 6967054
  102. Demonstration of multiple phenotypic diversity in a murine melanoma of recent origin.
    J Natl Cancer Inst. 1981 Oct;67(4):947-56 PMID: 6944560
  103. 5-Fluorouracil and methotrexate combination chemotherapy: the effect of drug scheduling.
    Eur J Cancer Clin Oncol. 1981 Jul;17(7):831-7 PMID: 6949765
  104. Apparent reversion of stable in vitro genetic markers detected in tumour cells from spontaneous metastases.
    Nature. 1981 Jul 16;292(5820):242-5 PMID: 6894784
  105. Spontaneous fusion between Ehrlich ascites tumor cells and host cells in vivo: kinetics of hybridization, and concurrent changes in the histocompatiblity profile of the tumor after propagation in different host strains.
    Eur J Cancer. 1980 Apr;16(4):487-510 PMID: 7398720
  106. Differences in drug sensitivity among tumor cells from parental tumors, selected variants, and spontaneous metastases.
    Cancer Res. 1981 Aug;41(8):3058-64 PMID: 7248962
  107. Cell variants showing differential susceptibility to ultraviolet light--induced transformation.
    Science. 1980 Jul 25;209(4455):505-7 PMID: 7394516
  108. Hormonal carcinogenesis: a novel hypothesis for the role of hormones.
    J Environ Pathol Toxicol. 1978 Sep-Oct;2(1):13-20 PMID: 722216
  109. Origin of the resistance of leukaemic cells to folic acid antagonists.
    Nature. 1952 Apr 12;169(4302):628-9 PMID: 14929259
  110. Viral "tumorigenesis" in man: cell markers in condylomata acuminata.
    Int J Cancer. 1976 Jan 15;17(1):57-61 PMID: 1248901
  111. Introduction of metastatic heterogeneity by short-term in vivo passage of a cloned transformed cell line.
    J Supramol Struct. 1979;12(2):227-43 PMID: 544937
  112. In vivo hybridisation of human tumour and normal hamster cells.
    Nature. 1974 Aug 23;250(5468):649-51 PMID: 4859359
  113. Variation in steroid 5 alpha-reductase activity in cloned human skin fibroblasts. Shift in phenotypic expression from high to low activity upon subcloning.
    J Biol Chem. 1981 Apr 25;256(8):3662-6 PMID: 6938516
  114. Mutations of Bacteria from Virus Sensitivity to Virus Resistance.
    Genetics. 1943 Nov;28(6):491-511 PMID: 17247100
  115. An approach to the problem of heterogeneity of human tumour-cell populations.
    Br J Cancer. 1979 May;39(5):570-7 PMID: 486313
  116. Heterogeneity of malignant cells from a human colonic carcinoma.
    Cancer Res. 1981 May;41(5):1751-6 PMID: 7214343
  117. Immunologic heterogeneity of tumor cell subpopulations from a single mouse mammary tumor.
    J Natl Cancer Inst. 1979 Dec;63(6):1457-63 PMID: 229294
  118. Restriction enzyme analysis of mouse cellular type C viral DNA: emergence of new viral sequences in spontaneous AKR/J lymphomas.
    Proc Natl Acad Sci U S A. 1979 Apr;76(4):1677-81 PMID: 221902
  119. Metabolic co-operation between biochemically marked mammalian cells in tissue culture.
    J Cell Sci. 1969 Mar;4(2):353-67 PMID: 5817085
  120. On the mechanism of tumor "concomitant immunity".
    Int J Cancer. 1981 Jun 15;27(6):847-56 PMID: 7287231
  121. Differential responses to x-irradiation of subpopulations of two heterogeneous human carcinomas in vitro.
    Cancer Res. 1982 Jul;42(7):2556-61 PMID: 7083148
  122. Quantitation of differential sensitivity of human-tumor stem cells to anticancer drugs.
    N Engl J Med. 1978 Jun 15;298(24):1321-7 PMID: 77475
  123. Heterogeneity in growth inhibition by beta-trans-retinoic acid of metastatic B16 melanoma clones and in vivo-selected cell variant lines.
    Cancer Res. 1979 Dec;39(12):4767-71 PMID: 498105
  124. Synthesis of glycoprotein, glycolipid, protein, and lipid in synchronized L5178Y cells.
    J Cell Biol. 1970 Apr;45(1):23-33 PMID: 5458998
  125. A critical analysis of tumor morphology and hormone treatments in the untreated and estrogen-treated responsive and refractory human prostatic carcinoma.
    Cancer. 1977 Dec;40(6):2836-50 PMID: 201356
  126. Interactions among clonal subpopulations affect stability of the metastatic phenotype in polyclonal populations of B16 melanoma cells.
    Proc Natl Acad Sci U S A. 1981 Oct;78(10):6226-30 PMID: 6947225
  127. Antigenic differences between primary methylcholanthrene-induced rat sarcomas and post-surgical recurrences.
    Int J Cancer. 1977 Jul 15;20(1):37-43 PMID: 71272
  128. High levels of intracellular bombesin characterize human small-cell lung carcinoma.
    Science. 1981 Dec 11;214(4526):1246-8 PMID: 6272398
  129. Heterogeneity of induced testicular interstitial cell tumors of mice as evidenced by steroid biosynthetic enzyme activities.
    Cancer Res. 1968 Feb;28(2):348-53 PMID: 5641524
  130. Heterogeneity of cancer cells from a single human colon carcinoma.
    Am J Med. 1981 Dec;71(6):949-56 PMID: 7315857
  131. Immune cytolysis in relation to the growth cycle of Chinese hamster cells.
    Cancer Res. 1971 Jul;31(7):925-9 PMID: 5560386
  132. Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma.
    Cancer Res. 1981 May;41(5):2008-13 PMID: 7214369
  133. Metastatic properties conferred on nonmetastatic tumors by hybridization of spleen B-lymphocytes with plasmacytoma cells.
    J Natl Cancer Inst. 1981 Nov;67(5):1079-87 PMID: 6975387
  134. Intratumor maturational heterogeneity within the murine myeloma MOPC-315.
    Cancer Res. 1981 Jan;41(1):187-91 PMID: 6969629
  135. Karyotypic, antigenic, and kidney-invasive properties of cell lines from fibrosarcomas arising in C3H/10T1/2 cells implanted subcutaneously attached to plastic plates.
    Cancer Res. 1979 Jun;39(6 Pt 1):2172-8 PMID: 445415
  136. Heterogeneity of human thymocytes and a malignant T-lymphoblast cell line, MOLT-3.
    Cancer Res. 1981 May;41(5):1664-8 PMID: 6971148
  137. Evidence for single-cell origin of 3-methylcholanthrene-induced fibrosarcomas in mice with cellular mosaicism.
    Cancer Res. 1982 May;42(5):1856-8 PMID: 7066900
  138. Genetic instability coupled to clonal selection as a mechanism for tumor progression in the Dunning R-3327 rat prostatic adenocarcinoma system.
    Cancer Res. 1982 Jun;42(6):2353-71 PMID: 7074614
  139. Neuroendocrine cells in serially passaged rat stomach cancers induced by MNNG.
    Int J Cancer. 1979 Apr 15;23(4):536-41 PMID: 437928
  140. Use of monoclonal antibodies to define the diversity of mammary tumor viral gene products in virions and mammary tumors of the genus Mus.
    Cancer Res. 1981 Apr;41(4):1451-9 PMID: 6163523
  141. Clonal sublines of rat neurotumor RT4 and cell differentiation. I. Isolation and characterization of cell lines and cell type conversion.
    Dev Biol. 1978 Sep;66(1):97-108 PMID: 751847
  142. Mammary tumor virus DNA as a marker for genotypic variance within hormone-responsive GR mouse mammary tumors.
    Cancer Res. 1982 Mar;42(3):1154-8 PMID: 6277477
  143. Specificity of arrest, survival, and growth of selected metastatic variant cell lines.
    Cancer Res. 1978 Nov;38(11 Pt 2):4105-11 PMID: 359132
  144. Effect of ovariectomy on serially transplanted rat mammary tumors induced by 7,12-dimethylbenz[a]anthracene.
    Eur J Cancer Clin Oncol. 1981 Jul;17(7):801-8 PMID: 6800801
  145. Mammary tumors from GR mice contain more than one population of mouse mammary tumor virus-infected cells.
    Virology. 1981 Aug;113(1):119-29 PMID: 6267780
  146. Studies correlating the growth rate of a tumor and its metastases and providing evidence for tumor-related systemic growth-retarding factors.
    Cancer Res. 1972 Feb;32(2):374-9 PMID: 4258017
  147. Separation and characterization of two component tumor lines within the AKR lymphoma, AKTB-1, by fluorescence-activated cell sorting and flow microfluorometry analysis. II. Differential histopathology of sIg+ and sIg- sublines.
    J Immunol. 1982 Apr;128(4):1832-8 PMID: 7061851
  148. Adhesive characteristics of tumor cell variants of high and low tumorigenic potential.
    J Natl Cancer Inst. 1980 May;64(5):1173-8 PMID: 6767875
  149. Characterization of metastatic heterogeneity among subpopulations of a single mouse mammary tumor: heterogeneity in phenotypic stability.
    Invasion Metastasis. 1983;3(1):22-31 PMID: 6677618
  150. Multicellular origin of fibrosarcomas in mice induced by the chemical carcinogen 3-methylcholanthrene.
    J Exp Med. 1979 Oct 1;150(4):878-87 PMID: 512585
  151. An examination of tumor antigen loss in spontaneous metastases.
    Invasion Metastasis. 1981;1(2):111-25 PMID: 6985358
  152. Cyclic biological expression in mouse mammary tumors.
    Science. 1982 Apr 2;216(4541):68-70 PMID: 7063874
  153. Differential expression of murine leukemia antigen on L1210 parental and drug-resistant sublines.
    Cancer Res. 1981 Dec;41(12 Pt 1):4934-7 PMID: 7306993
  154. Biological and experimental consequences of the zonal composition of solid tumors.
    Cancer Res. 1981 Aug;41(8):3266-7 PMID: 7248979
  155. Cell cycle-dependent immune lysis of Moloney virus-transformed lymphocytes: presence of viral antigen, accessibility to antibody, and complement activation.
    Proc Natl Acad Sci U S A. 1971 Oct;68(10):2584-8 PMID: 4944633
  156. The clonal evolution of tumor cell populations.
    Science. 1976 Oct 1;194(4260):23-8 PMID: 959840
  157. Growth interaction in vivo between tumor subpopulations derived from a single mouse mammary tumor.
    Cancer Res. 1980 Nov;40(11):3977-81 PMID: 7471048
  158. Analysis of antigenic heterogeneity within individual 3-methylcholanthrene-induced mouse sarcomas.
    J Natl Cancer Inst. 1970 Nov;45(5):1039-45 PMID: 18605432
  159. Ultrastructure of the hormone-dependent N-nitrosomethylurea-induced mammary carcinoma of the rat.
    Cancer Res. 1980 Sep;40(9):3112-5 PMID: 7427929
  160. Multistep origin of tumor-forming ability in Chinese hamster embryo fibroblast cells.
    Cancer Res. 1982 Feb;42(2):389-96 PMID: 6799186
  161. Differential sensitivity of two murine leukaemia sublines to cytolysis by Corynebacterium parvum-activated macrophages.
    Br J Cancer. 1981 Dec;44(6):819-27 PMID: 7326193
  162. Characterization of a variant-producing tumor cell line from a heterogeneous strain BALB/cfC3H mouse mammary tumor.
    Cancer Res. 1981 Apr;41(4):1293-300 PMID: 6260334
  163. Detection of inapparent nodule-transformed cells in the mammary gland tissues of virgin female BALB/cfC3H mice.
    Cancer Res. 1978 Jul;38(7):2103-11 PMID: 207423
  164. Selection and characterization in culture of mammary tumor cells with distinctive growth properties in vivo.
    Cancer Res. 1980 Jun;40(6):1812-9 PMID: 7371012
  165. Tumor metastases and cell-mediated immunity in a model system in DBA/2 mice. IV. Antigenic differences between a metastasizing variant and the parental tumor line revealed by cytotoxic T lymphocytes.
    Int J Cancer. 1979 Feb;23(2):245-52 PMID: 83969
  166. Metastasis results from preexisting variant cells within a malignant tumor.
    Science. 1977 Aug 26;197(4306):893-5 PMID: 887927
  167. Heterogeneous chemosensitivities of subpopulations of human glioma cells in culture.
    Cancer Res. 1982 Mar;42(3):992-8 PMID: 7199383
  168. Radiation and melanoma: response of B16 mouse tumor cells and clonal lines to in vitro irradiation.
    Radiat Res. 1979 Nov;80(2):259-76 PMID: 504576
  169. Schedule-dependent synergism of combinations of hydroxyurea with adriamycin and 1-beta-D-arabinofuranosylcytosine with adriamycin.
    Cancer Res. 1981 Oct;41(10):3881-4 PMID: 7284997
Article Info
Journal
Cancer metastasis reviews
Abbr.
Cancer Metastasis Rev
ISSN
0167-7659
DOI
10.1007/BF00046903
Published
1983-00-00
Pages
5-23
Language
English
Region
Netherlands
NLM ID
8605731
Subset
IM
Grants
NCI NIH HHS · CA-27419 · United States
External Links
PubMed source DOI: 10.1007/BF00046903 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2