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PMID: 6607312 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Identification of a specific interleukin 1 inhibitor in the urine of febrile patients.

The Journal of experimental medicine ·Vol. 159 ·No. 1 ·1984-01-01 ·Pages 126-36

Liao Z, Grimshaw RS, Rosenstreich DL

Abstract

The urine of febrile patients has been found to contain high concentrations of an inhibitor of interleukin 1 (IL-1)-induced thymocyte proliferation. The inhibitor is specific for IL-1 and does not block the effects of interleukin 2 (IL-2) or phytohemagglutin (PHA) on thymocytes, and it is not nonspecifically toxic for these cells. IL-1 inhibitor can be found in the urine of normal individuals and afebrile patients, but is present in increased concentrations in the urine of patients with fever of diverse etiologies. Preliminary physicochemical characterization indicates that the inhibitor is a 20-40-kdalton protein.

MeSH Terms
Animals Binding, Competitive Fever/immunology,urine Humans Interleukin 1 Receptor Antagonist Protein Interleukin-1/physiology,urine Lymphocyte Activation Mice Molecular Weight Phytohemagglutinins/pharmacology Proteins/isolation & purification Proteinuria/urine Sialoglycoproteins T-Lymphocytes/immunology
Chemicals
IL1RN protein, human Il1rn protein, mouse Interleukin 1 Receptor Antagonist Protein Interleukin-1 Phytohemagglutinins Proteins Sialoglycoproteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Liao Z
Grimshaw R S
Rosenstreich D L
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21 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.159.1.126
Published
1984-01-01
Pages
126-36
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2187209
Subset
IM
Grants
NIAID NIH HHS · AI-17934 · United States
External Links
PubMed source DOI: 10.1084/jem.159.1.126 PMC Full Text View journal details
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