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PMID: 6601053 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Recognition of Db and Kb gene products by influenza-specific cytotoxic T cells.

Immunogenetics ·Vol. 17 ·No. 3 ·1983-00-00 ·Pages 283-94

Townsend AR, Taylor PM, Mellor AL, Askonas BA

Abstract

A series of 16 H-2b-restricted, A influenza virus-specific cytotoxic T-cell clones are described and characterized. One is Kb restricted, the others Db restricted. The factors governing Kb or Db restriction patterns seen in the mixed populations from which clones are derived are investigated. The Kb-restricted clone does not recognize Kb mutant bml and influenza and all 15 Db-restricted clones do not recognize Db mutant bml4 and A influenza virus; these results are discussed in the light of findings in a variety of other viral systems. Representative Kb- and Db-restricted clones were used to assess the functional properties of cloned cosmids containing either Kb or Db genes expressed in transformed L-cells (k haplotype). The expression products of both cosmids functioned efficiently as mutually exclusive restriction elements for A influenza virus recognition.

MeSH Terms
Animals Antigens, Viral/immunology Cytotoxicity, Immunologic Female H-2 Antigens/immunology Influenza A virus/immunology Mice Mice, Inbred C57BL T-Lymphocytes, Cytotoxic/immunology
Chemicals
Antigens, Viral H-2 Antigens
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Townsend A R
Taylor P M
Mellor A L
Askonas B A
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29 references, click to expand
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF00364412
Published
1983-00-00
Pages
283-94
Language
English
Region
United States
NLM ID
0420404
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00364412 View journal details
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