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PMID: 6585819 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Cardiac alpha- and beta-myosin heavy chain genes are organized in tandem.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 81 ·No. 9 ·1984-05-00 ·Pages 2626-30

Mahdavi V, Chambers AP, Nadal-Ginard B

Abstract

Two ventricular myosin heavy chains (MHCs), alpha and beta, which exhibit different levels of ATPase activity, are differentially expressed during development, in response to thyroid hormone and in several pathological conditions. We have isolated and analyzed the structure of the genes coding for alpha- and beta-MHC mRNAs in the rat. Detailed analysis of eight overlapping MHC genomic clones shows that the alpha- and beta-MHC genes are organized in tandem and span 50 kilobases of the chromosome. The beta-MHC gene, predominantly expressed in late fetal life, is located 4 kilobases upstream from the alpha-MHC gene, predominantly expressed in the adult. These two genes are very closely related at the nucleotide sequence level, suggesting that they have arisen by duplication of a common ancestor, yet their expression in the ventricular myocardium has been shown to be regulated in an antithetic fashion by thyroid hormone.

MeSH Terms

Animals Base Sequence Biological Evolution Genes Genetic Linkage Heart/physiology Myosins/genetics Operon Poly A/genetics Rats

Chemicals

Poly A Myosins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Mahdavi V

Chambers A P

Nadal-Ginard B

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25 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.81.9.2626

Published

1984-05-00

Pages

2626-30

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC345122

Subset

Databases

GENBANK

K01463, K01464, K01465

External Links

PubMed source DOI: 10.1073/pnas.81.9.2626 PMC Full Text View journal details

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Cardiac alpha- and beta-myosin heavy chain genes are organized in tandem.

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