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PMID: 6487275 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

N-Acetylglutamate in rat liver during foetal development.

The Biochemical journal ·Vol. 222 ·No. 3 ·1984-09-15 ·Pages 837-8

Van Dijk M, Lund P

Abstract

N-Acetylglutamate is present in foetal rat liver at 17 days' gestation. The tissue content (approx. 50 nmol/g wet wt.) remains constant during later foetal life. The appearance of N-acetylglutamate does not parallel the developmental pattern of the urea cycle.

MeSH Terms

Animals Gestational Age Glutamates/metabolism Liver/embryology,metabolism Rats Rats, Inbred Strains

Chemicals

Glutamates N-acetylglutamic acid

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Van Dijk M

Lund P

References (11)

11 references, click to expand

Inhibition by propionyl-coenzyme A of N-acetylglutamate synthetase in rat liver mitochondria. A possible explanation for hyperammonemia in propionic and methylmalonic acidemia.
J Clin Invest. 1979 Dec;64(6):1544-51 PMID: 500823
The regulation of carbamyl phosphate synthetase (ammonia) in rat liver mitochondria. Effects of acetylglutamate concentration and ATP translocation.
J Biol Chem. 1980 Jun 10;255(11):5051-7 PMID: 6246096
Failure of the normal ureagenic response to amino acids in organic acid-loaded rats. Proposed mechanism for the hyperammonemia of propionic and methylmalonic acidemia.
J Clin Invest. 1980 Sep;66(3):484-92 PMID: 7400325
N-acetylglutamate synthetase deficiency: a disorder of ammonia detoxication.
N Engl J Med. 1981 Feb 26;304(9):543 PMID: 7453791
Developmental changes of citrullinogenesis, mitochondrial N-acetylglutamate content and N-acetylglutamate synthetase in fetal and neonatal rats.
Biochimie. 1983 Jan;65(1):1-6 PMID: 6403054
Interactions between alpha-ketoisovalerate metabolism and the pathways of gluconeogenesis and urea synthesis in isolated hepatocytes.
J Biol Chem. 1983 Mar 25;258(6):3673-81 PMID: 6833225
Inhibition of ureagenesis by valproate in rat hepatocytes. Role of N-acetylglutamate and acetyl-CoA.
Biochem J. 1983 Oct 15;216(1):233-6 PMID: 6418145
Is N-acetylglutamate a short-term regulator of urea synthesis?
Biochem J. 1984 Mar 15;218(3):991-4 PMID: 6721845
Liver growth in early postpartum rat.
Dev Biol. 1962 Feb;4:108-16 PMID: 14481807
[EMBRYONAL ERYTHROPOIESIS AND THE NUCLEIC ACID CONTENT IN THE EMBRYONAL LIVER IN WHOLE-BODY IRRADIATED RATS].
Acta Biol Med Ger. 1964;12:354-64 PMID: 14186603
[A simple technic for extremely rapid freezing of large pieces of tissue].
Pflugers Arch Gesamte Physiol Menschen Tiere. 1960;270:399-412 PMID: 13845757

Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj2220837

Published

1984-09-15

Pages

837-8

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1144251

Subset

External Links

PubMed source DOI: 10.1042/bj2220837 PMC Full Text View journal details

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N-Acetylglutamate in rat liver during foetal development.

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