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PMID: 6430226 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Identification of an envelope mutation (env-10) resulting in increased antibiotic susceptibility and pyocin resistance in a clinical isolate of Neisseria gonorrhoeae.

Antimicrobial agents and chemotherapy ·Vol. 25 ·No. 6 ·1984-06-00 ·Pages 767-9

Shafer WM, Guymon LF, Lind I, Sparling PF

Abstract

A mutation (env-10) conferring increased susceptibility to drugs, dyes, and detergents was detected in a clinical isolate of Neisseria gonorrhoeae. In certain strains, env-10 also affected susceptibility to pyocins. This mutation was phenotypically similar to but genotypically distinct from previously described env mutations.

MeSH Terms

Anti-Bacterial Agents/pharmacology Bacteriocins/pharmacology Cell Membrane Cell Wall Drug Resistance, Microbial Microbial Sensitivity Tests Mutation Neisseria gonorrhoeae/drug effects,genetics,ultrastructure Pyocins/pharmacology

Chemicals

Anti-Bacterial Agents Bacteriocins Pyocins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Shafer W M

Guymon L F

Lind I

Sparling P F

References (7)

7 references, click to expand

Loss of low-level antibiotic resistance in Neisseria gonorrhoeae due to env mutations.
J Bacteriol. 1975 Nov;124(2):750-6 PMID: 810480
Altered crystal violet permeability and lytic behavior in antibiotic-resistant and -sensitive mutants of Neisseria gonorrhoeae.
J Bacteriol. 1975 Nov;124(2):757-63 PMID: 810481
Mutations to increased antibiotic sensitivity in naturally-occurring gonococci.
Nature. 1978 Jan 19;271(5642):242-4 PMID: 414141
Cell envelope alterations in antibiotic-sensitive and-resistant strains of Neisseria gonorrhoeae.
J Bacteriol. 1978 Oct;136(1):391-401 PMID: 101519
Identification of a new genetic site (sac-3+) in Neisseria gonorrhoeae that affects sensitivity to normal human serum.
Infect Immun. 1982 Mar;35(3):764-9 PMID: 6802757
Pyocin-resistant lipopolysaccharide mutans of Neisseria gonorrhoeae: alterations in sensitivity to normal human serum and polymyxin B.
Infect Immun. 1982 May;36(2):541-7 PMID: 6282751
Gonococcal strains from homosexual men have outer membranes with reduced permeability to hydrophobic molecules.
Infect Immun. 1982 Aug;37(2):432-8 PMID: 6811431

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.25.6.767

Published

1984-06-00

Pages

767-9

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC185638

Subset

Grants

NIAID NIH HHS · AI06369 · United States

NIAID NIH HHS · AI15036 · United States

External Links

PubMed source DOI: 10.1128/AAC.25.6.767 PMC Full Text View journal details

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Identification of an envelope mutation (env-10) resulting in increased antibiotic susceptibility and pyocin resistance in a clinical isolate of Neisseria gonorrhoeae.

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