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PMID: 6429346 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

A new method for calculating evolutionary substitution rates.

Journal of molecular evolution ·Vol. 20 ·No. 1 ·1984-00-00 ·Pages 86-93

Lanave C, Preparata G, Saccone C, Serio G

Abstract

In this paper we present a new method for analysing molecular evolution in homologous genes based on a general stationary Markov process. The elaborate statistical analysis necessary to apply the method effectively has been performed using Monte Carlo techniques. We have applied our method to the silent third position of the codon of the five mitochondrial genes coding for identified proteins of four mammalian species (rat, mouse, cow and man). We found that the method applies satisfactorily to the three former species, while the last appears to be outside the scope of the present approach. The method allows one to calculate the evolutionarily effective silent substitution rate (vs) for mitochondrial genes, which in the species mentioned above is 1.4 X 10(-8) nucleotide substitutions per site per year. We have also determined the divergence time ratios between the couples mouse-cow/rat-mouse and rat-cow/rat-mouse. In both cases this value is approximately 1.4.

MeSH Terms
Animals Biological Evolution Cattle Codon/genetics Genes Humans Markov Chains Mice Mitochondria/metabolism Monte Carlo Method Proteins/genetics Rats Stochastic Processes
Chemicals
Codon Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Lanave C
Preparata G
Saccone C
Serio G
References (21)
21 references, click to expand
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Article Info
Journal
Journal of molecular evolution
Abbr.
J Mol Evol
ISSN
0022-2844
DOI
10.1007/BF02101990
Published
1984-00-00
Pages
86-93
Language
English
Region
Germany
NLM ID
0360051
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02101990 View journal details
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