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PMID: 6389355 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

H-2-linked genes which modify resistance of C57BL/10 mice to subcutaneous infection with Mycobacterium lepraemurium.

Infection and immunity ·Vol. 46 ·No. 3 ·1984-12-00 ·Pages 635-8

Curtis J, Akuffo-Adu H, Turk JL

Abstract

Strains of C57BL/10 mice with recombinants within the H-2 complex were used to map the genes which control the mononuclear cell response at the infection site and modify resistance to subcutaneous infection with Mycobacterium lepraemurium. Strains with b in the K-E beta regions of the H-2 complex mounted a more rapid cellular response in the infected footpad and were more resistant than mice with d or k in the K-E beta regions. Significant differences between strains with k in the K-E beta regions appeared to be controlled by a gene in the D region.

MeSH Terms
Animals Genetic Linkage H-2 Antigens/genetics Immunity, Innate Major Histocompatibility Complex Mice Mice, Inbred C57BL/genetics,immunology Mycobacterium Infections/genetics,immunology,microbiology Mycobacterium lepraemurium
Chemicals
H-2 Antigens
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Curtis J
Akuffo-Adu H
Turk J L
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20 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.46.3.635-638.1984
Published
1984-12-00
Pages
635-8
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC261588
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.46.3.635-638.1984 PMC Full Text View journal details
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