Home LiteratureArticle Details
PMID: 6365787 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Resistance to subcutaneous infection with Mycobacterium lepraemurium is controlled by more than one gene.

Infection and immunity ·Vol. 43 ·No. 3 ·1984-03-00 ·Pages 925-30

Curtis J, Turk JL

Abstract

The resistance of C57BL (high) and BALB/c (low) mice, their F1 hybrids, and the offspring derived from backcrosses of the F1 to both parental strains was assessed at 20 weeks after subcutaneous infection with 10(7) Mycobacterium lepraemurium organisms. The numbers of bacilli recovered from the infected foot and draining lymph node indicated that resistance to subcutaneous infection is controlled by more than one non-H-2-linked gene of intermediate dominance. In general, female mice were more resistant than males.

MeSH Terms
Animals Crosses, Genetic Female Genes, Dominant Genetic Linkage Immunity, Innate Lymph Nodes/microbiology Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mycobacterium Infections/genetics,microbiology Mycobacterium lepraemurium Sex Characteristics
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Curtis J
Turk J L
References (22)
22 references, click to expand
  1. H-2 linkage control of resistance to subcutaneous infection with Mycobacterium lepraemurium.
    Infect Immun. 1982 Nov;38(2):434-9 PMID: 6815095
  2. Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene.
    J Immunol. 1980 Jan;124(1):20-4 PMID: 6985638
  3. Regulation of Leishmania populations within the host. II. genetic control of acute susceptibility of mice to Leishmania donovani infection.
    Clin Exp Immunol. 1977 Oct;30(1):130-40 PMID: 606434
  4. Strain difference of delayed-type hypersensitivity to BCG and its genetic control in mice.
    Infect Immun. 1978 Dec;22(3):657-64 PMID: 365763
  5. Phenotypic expression of genetically controlled host resistance to Listeria monocytogenes.
    Infect Immun. 1979 Jul;25(1):345-51 PMID: 113346
  6. Induction of cell-mediated immunity to Mycobacterium lepraemurium in susceptible mice.
    Infect Immun. 1977 Dec;18(3):654-9 PMID: 338487
  7. Macrophages and protective immunity in Mycobacterium lepraemurium infections in a 'resistant' (C57Bl) and a 'susceptible' (BALB/c) mouse strain.
    Clin Exp Immunol. 1982 Feb;47(2):243-52 PMID: 6804142
  8. Resistance and susceptibility of mice to bacterial infection: genetics of listeriosis.
    Infect Immun. 1978 Mar;19(3):755-62 PMID: 305895
  9. The walls of Mycobacterium lepraemurium: chemistry and ultrastructure.
    J Gen Microbiol. 1971 Dec;69(3):313-24 PMID: 4335581
  10. Immunological regulation of experimental cutaneous leishmaniasis. 1. Immunogenetic aspects of susceptibility to Leishmania tropica in mice.
    Parasite Immunol. 1980 Winter;2(4):303-14 PMID: 7220075
  11. Adoptive transfer of immunity and suppression by cells and serum in early Mycobacterium lepraemurium infections of mice.
    Parasite Immunol. 1979 Summer;1(2):159-66 PMID: 399335
  12. Classification of mouse leprosy.
    Jpn J Exp Med. 1959 Dec;29:651-63 PMID: 14404953
  13. Murine malaria: genetic control of resistance to Plasmodium chabaudi.
    Infect Immun. 1982 Oct;38(1):80-8 PMID: 7141699
  14. Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice.
    J Immunol. 1981 Dec;127(6):2417-21 PMID: 6795274
  15. A lack of correlation between antigen-specific cellular reactions and resistance to Mycobacterium lepraemurium infection in mice.
    Immunology. 1981 Jun;43(2):293-301 PMID: 7019051
  16. Effect of macrocyclon in acute and chronic pulmonary tuberculous infection in mice as shown by viable and total bacterial counts.
    Br J Exp Pathol. 1960 Aug;41:414-21 PMID: 13711882
  17. Genetic regulation of resistance to intracellular pathogens.
    Nature. 1982 Jun 10;297(5866):506-9 PMID: 7045675
  18. Inbred mouse strain resistance to Mycobacterium lepraemurium follows the Ity/Lsh pattern.
    Immunology. 1982 Sep;47(1):149-56 PMID: 6749659
  19. Influence of H-2 complex on acquired resistance to Leishmania donovani infection in mice.
    Nature. 1980 Jan 3;283(5742):72-4 PMID: 6765984
  20. Genetics of murine resistance to Trypanosoma cruzi.
    Infect Immun. 1982 Feb;35(2):546-51 PMID: 6799406
  21. Genetics of resistance to infection with Salmonella typhimurium in mice.
    J Infect Dis. 1976 Jan;133(1):72-8 PMID: 1107437
  22. Are the Lsh and Ity disease resistance genes at one locus on mouse chromosome 1?
    Nature. 1982 Jun 10;297(5866):510-1 PMID: 7045676
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.43.3.925-930.1984
Published
1984-03-00
Pages
925-30
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC264272
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.43.3.925-930.1984 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2