Home LiteratureArticle Details
PMID: 6387444 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The gene and the pseudogene for mouse p53 cellular tumor antigen are located on different chromosomes.

Molecular and cellular biology ·Vol. 4 ·No. 8 ·1984-08-00 ·Pages 1638-40

Czosnek HH, Bienz B, Givol D, Zakut-Houri R, Pravtcheva DD, Ruddle FH, Oren M

Abstract

The chromosomal assignments of the two genes encoding the murine p53 cellular tumor antigen were determined by using a panel of mouse-Chinese hamster somatic cell hybrid clones and a mouse p53-specific cDNA clone. One gene, probably the functional member of the family, was found to be on chromosome 11. The other gene, which is probably a processed pseudogene, was assigned to chromosome 14. The potential relevance of these findings to documented cases of chromosome 11 trisomy are also discussed.

MeSH Terms
Animals Chromosome Mapping Cloning, Molecular Cricetinae Cricetulus DNA/analysis Genes Hybrid Cells/physiology Mice Neoplasm Proteins/genetics Phosphoproteins/genetics Trisomy Tumor Suppressor Protein p53
Chemicals
Neoplasm Proteins Phosphoproteins Tumor Suppressor Protein p53 DNA
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Czosnek H H
Bienz B
Givol D
Zakut-Houri R
Pravtcheva D D
Ruddle F H
Oren M
References (19)
19 references, click to expand
  1. A review of enzyme polymorphism, linkage and electrophoretic conditions for mouse and somatic cell hybrids in starch gels.
    J Histochem Cytochem. 1973 Dec;21(12):1066-81 PMID: 4587225
  2. Detection of specific sequences among DNA fragments separated by gel electrophoresis.
    J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
  3. Tumorigenicity of mouse-human diploid hybrids in nude mice.
    Science. 1975 Dec 19;190(4220):1200-2 PMID: 173020
  4. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.
    J Mol Biol. 1977 Jun 15;113(1):237-51 PMID: 881736
  5. Association of a murine 53,000-dalton phosphoprotein with simian virus 40 large-T antigen in transformed cells.
    J Virol. 1980 Apr;34(1):213-24 PMID: 6246255
  6. Characterization of the complex between SV40 large T antigen and the 53K host protein in transformed mouse cells.
    Cold Spring Harb Symp Quant Biol. 1980;44 Pt 1,:179-87 PMID: 6253132
  7. Chromosomal location of structural genes encoding murine immunoglobulin lambda light chains. Genetics of murine lambda light chains.
    J Exp Med. 1981 Apr 1;153(4):793-800 PMID: 6265582
  8. SV40 T antigen binds specifically to a cellular 53 K protein in vitro.
    Nature. 1981 Jul 2;292(5818):63-5 PMID: 6268984
  9. Restriction point control of cell growth by a labile protein: evidence for increased stability in transformed cells.
    Proc Natl Acad Sci U S A. 1982 Jan;79(2):436-40 PMID: 6952194
  10. DNAase I sensitivity of genes expressed during myogenesis.
    Nucleic Acids Res. 1982 May 25;10(10):3085-98 PMID: 6285287
  11. Microinjection of monoclonal antibody to protein p53 inhibits serum-induced DNA synthesis in 3T3 cells.
    Proc Natl Acad Sci U S A. 1982 Oct;79(20):6309-12 PMID: 6292898
  12. p53 protein and control of growth.
    Nature. 1983 Jun 23-29;303(5919):660-1 PMID: 6343891
  13. Pre-crisis mouse cells show strain-specific covariation in the amount of 54-kilodalton phosphoprotein and in susceptibility to transformation by simian virus 40.
    Proc Natl Acad Sci U S A. 1983 Sep;80(18):5670-4 PMID: 6310588
  14. Protein p53 and inducer-mediated erythroleukemia cell commitment to terminal cell division.
    Proc Natl Acad Sci U S A. 1983 Oct;80(19):5919-22 PMID: 6351070
  15. Chromosomes and cancer in the mouse: studies in tumors, established cell lines, and cell hybrids.
    Adv Cancer Res. 1983;39:153-82 PMID: 6312778
  16. Analysis of recombinant DNA clones specific for the murine p53 cellular tumor antigen.
    EMBO J. 1983;2(10):1633-9 PMID: 6315396
  17. A single gene and a pseudogene for the cellular tumour antigen p53.
    Nature. 1983 Dec 8-14;306(5943):594-7 PMID: 6646235
  18. Chromosomal assignment of the murine gene encoding the transformation-related protein p53.
    Mol Cell Biol. 1984 Feb;4(2):383-5 PMID: 6366521
  19. The genes coding for the muscle contractile proteins, myosin heavy chain, myosin light chain 2, and skeletal muscle actin are located on three different mouse chromosomes.
    EMBO J. 1982;1(11):1299-305 PMID: 6897916
Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.4.8.1638-1640.1984
Published
1984-08-00
Pages
1638-40
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC368959
Subset
IM
External Links
PubMed source DOI: 10.1128/mcb.4.8.1638-1640.1984 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2