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PMID: 6384729 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

The use of extragenic suppressors to define genes involved in protein export in Escherichia coli.

Molecular & general genetics : MGG ·Vol. 196 ·No. 1 ·1984-00-00 ·Pages 24-7

Brickman ER, Oliver DB, Garwin JL, Kumamoto C, Beckwith J

Abstract

The secA gene codes for a membrane component involved in protein export in E. coli. In order to define other genes whose products play such a role, we have characterized extragenic suppressors of a secA(Ts) mutation. These suppressors fall into at least three genetic loci. One such locus is the prlA gene, previously identified by mutations which suppress signal sequence mutants. Thus, this approach may allow the identification of new genes involved in the export process.

MeSH Terms
Bacterial Proteins/genetics,metabolism Chromosome Mapping Escherichia coli/genetics,metabolism Genes, Bacterial Genetic Linkage Membrane Proteins/genetics Mutation Suppression, Genetic
Chemicals
Bacterial Proteins Membrane Proteins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Brickman E R
Oliver D B
Garwin J L
Kumamoto C
Beckwith J
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21 references, click to expand
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Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00334087
Published
1984-00-00
Pages
24-7
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00334087
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