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PMID: 6181418 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum.

Nature ·Vol. 299 ·No. 5885 ·1982-10-21 ·Pages 691-8

Walter P, Blobel G

Abstract

In addition to its previously characterized, six different polypeptide components, signal recognition protein--which functions in protein translocation across and integration into the endoplasmic reticulum membrane--contains a 7S RNA molecule. The RNA is closely identified with the small cytoplasmic 7SL RNA and is required for both structural and functional properties of signal recognition protein--which we therefore rename signal recognition particle.

MeSH Terms
Animals Base Sequence Biological Transport Dogs Endoplasmic Reticulum/physiology Macromolecular Substances Membrane Proteins/physiology Peptides/metabolism,physiology Protein Precursors/metabolism Protein Sorting Signals RNA/physiology RNA, Small Nuclear Ribonucleoproteins/physiology Ribonucleoproteins, Small Nuclear Ribosomes/metabolism
Chemicals
Macromolecular Substances Membrane Proteins Peptides Protein Precursors Protein Sorting Signals RNA, Small Nuclear Ribonucleoproteins Ribonucleoproteins, Small Nuclear RNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Walter P
Blobel G
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
Published
1982-10-21
Pages
691-8
Language
English
Region
England
NLM ID
0410462
Subset
IM
Grants
NIGMS NIH HHS · GM-27155 · United States
Databases
GENBANK
J01853
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