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PMID: 6353166 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Cyclic variations in sensitivity to X-irradiation during meiosis in Saccharomyces cerevisiae.

Molecular & general genetics : MGG ·Vol. 191 ·No. 2 ·1983-00-00 ·Pages 314-8

Kelly SL, Merrill C, Parry JM

Abstract

Cyclic variation in mutation induction and lethality was found following X-irradiation during meiosis in Saccharomyces cerevisiae. An enhanced mutagenic response was found in meiotic G1 phase cells in comparison to cells later in meiosis, similar to the response shown during mitosis, but meiotic G1 phase cells appeared more resistant to the lethal effects of X-irradiation than mitotic G1 phase cells. Resistance to the lethal effects of X-rays was found during meiotic DNA synthesis in the strain SK1, which may indicate the operation of a sister-chromatid exchange repair mechanism. A difference was found between gene conversion which appeared to be at a maximum by the end of meiotic DNA synthesis and reciprocal recombination, which could be induced up to prophase I.

MeSH Terms
DNA Repair/radiation effects DNA, Fungal/biosynthesis Gene Conversion/radiation effects Meiosis/radiation effects Mutation Recombination, Genetic/radiation effects Saccharomyces cerevisiae/genetics,metabolism,radiation effects Time Factors
Chemicals
DNA, Fungal
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kelly S L
Merrill C
Parry J M
References (27)
27 references, click to expand
  1. The repair of double-strand breaks in DNA; a model involving recombination.
    J Theor Biol. 1976 Jun;59(1):97-106 PMID: 940351
  2. Cell-cycle dependent changes in sensitivity to gamma-rays in synchronously dividing yeast culture.
    Exp Cell Res. 1974 Mar 15;84(1):431-5 PMID: 4594107
  3. Methods in sporulation and germination of yeasts.
    Methods Cell Biol. 1975;11:45-69 PMID: 1102856
  4. Mitotic recombination: mismatch correction and replicational resolution of Holliday structures formed at the two strand stage in Saccharomyces.
    Mol Gen Genet. 1981;183(2):252-63 PMID: 7035826
  5. A genetic study of x-ray sensitive mutants in yeast.
    Mutat Res. 1974 Sep;24(3):281-92 PMID: 4606119
  6. Genetic control of budding-cell resistance in the diploid yeast Saccharomyces cerevisiae exposed to gamma-radiation.
    Mutat Res. 1982 Aug;95(2-3):213-24 PMID: 6750384
  7. The relevance of the nuclear division cycle to radiosensitivity in yeast.
    Mol Gen Genet. 1978 Jul 4;162(3):277-86 PMID: 355834
  8. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.
    Biochem J. 1956 Feb;62(2):315-23 PMID: 13293190
  9. Measuring spontaneous mutation rates in yeast.
    Methods Cell Biol. 1978;20:1-24 PMID: 357921
  10. The timing of UV mutagenesis in yeast: a pedigree analysis of induced recessive mutation.
    Genetics. 1977 Oct;87(2):237-48 PMID: 336459
  11. Meiotic recombination and synaptonemal complexes in Saccharomyces cerevisiae.
    Mol Gen Genet. 1978 Oct 30;166(2):151-9 PMID: 370542
  12. A comparison of the radiosensitivity of stationary, exponential and G1 phase wild type and repair deficient yeast cultures: supporting evidence for stationary phase yeast cells being in G0.
    Int J Radiat Biol Relat Stud Phys Chem Med. 1982 Feb;41(2):215-20 PMID: 6978312
  13. Repair of DNA double-strand breaks requires two homologous DNA duplexes.
    Mol Biol Rep. 1977 Dec;3(6):437-42 PMID: 339056
  14. Differential effect of UV irradiation on induction of intragenic and intergenic recombination during commitment to meiosis in Saccharomyces cerevisiae.
    Mutat Res. 1980 Nov;73(1):69-79 PMID: 7019682
  15. The role of repair mechanisms in the variations of ultraviolet and gamma-radiation sensitivity during the cell cycle of Schizosaccharomyces pombe.
    Radiat Res. 1973 Dec;56(3):528-39 PMID: 4767133
  16. A general model for genetic recombination.
    Proc Natl Acad Sci U S A. 1975 Jan;72(1):358-61 PMID: 1054510
  17. The relation of radioresistance to budding in Saccharomyces cerevisiae.
    Arch Biochem Biophys. 1954 Mar;49(1):110-22 PMID: 13139676
  18. Radiosensitivity in relation to the cell cycle and recovery from x-ray sublethal damage in diploid yeast.
    Exp Cell Res. 1967 May;46(2):292-300 PMID: 6028141
  19. Induction of DNA double-strand breaks by X-rays in a radiosensitive strain of the yeast Saccharomyces cerevisiae.
    Mutat Res. 1975 Dec;30(3):327-34 PMID: 1105165
  20. Carbohydrate metabolism during ascospore development in yeast.
    J Bacteriol. 1974 Apr;118(1):8-14 PMID: 4595206
  21. The influence of cell size on U.V. induced cell cycle variation in lethality and mitotic recombination in the yeast Saccharomyces cerevisiae.
    Int J Radiat Biol Relat Stud Phys Chem Med. 1981 Sep;40(3):327-31 PMID: 7026476
  22. Sporulation synchrony of Saccharomyces cerevisiae grown in various carbon sources.
    J Bacteriol. 1973 Nov;116(2):925-30 PMID: 4583256
  23. Folded chromosomes of Saccharomyces cerevisiae: comparison of response to sporulation medium, arrest at start, and G0 arrest.
    Chromosoma. 1980;81(3):379-91 PMID: 7004804
  24. Cell-cycle-specific repair of DNA double strand breaks in Saccharomyces cerevisiae.
    Radiat Res. 1980 Jun;82(3):547-58 PMID: 6992192
  25. The induction of mutation and recombination following UV irradiation during meiosis in Saccharomyces cerevisiae.
    Mutat Res. 1983 Mar;108(1-3):109-20 PMID: 6339882
  26. Genetic control of diploid recovery after gamma-irradiation in the yeast Saccharomyces cerevisiae.
    Mutat Res. 1980 Dec;73(2):251-65 PMID: 7007877
  27. The repair of double-strand breaks in the nuclear DNA of Saccharomyces cerevisiae and its genetic control.
    Mol Gen Genet. 1976 Jan 16;143(2):119-29 PMID: 765749
Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00334832
Published
1983-00-00
Pages
314-8
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00334832
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