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PMID: 6343242 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

A BALB/c congenic strain of mice that carries a genetic locus (Ityr) controlling resistance to intracellular parasites.

Infection and immunity ·Vol. 40 ·No. 3 ·1983-06-00 ·Pages 1234-5

Potter M, O'Brien AD, Skamene E, Gros P, Forget A, Kongshavn PA, Wax JS

Abstract

BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b congenic mice were developed by introgressively backcrossing the Idh-1b and Pep-3b markers of DBA/2 mice onto the BALB/c pi mice. This introduced a 30-centimorgan chromosome 1 segment of DBA/2 chromatin that contained the Ityr gene. BALB/c.DBA/2 Idh-1b-Ityr-Pep-3b mice were resistant to in vivo infections by Salmonella typhimurium, Mycobacterium bovis, and Leishmania donovani.

MeSH Terms

Animals Crosses, Genetic Genes Immunity, Innate Leishmaniasis, Visceral/genetics,immunology Mice Mice, Inbred BALB C Mice, Inbred DBA Mycobacterium bovis Salmonella Infections, Animal/genetics,immunology Salmonella typhimurium Tuberculosis/genetics,immunology

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Potter M

O'Brien A D

Skamene E

Gros P

Forget A

Kongshavn P A

Wax J S

References (12)

12 references, click to expand

Inheritance, hormonal regulation and properties of polymorphic murine antigens Mud1 and Mud2.
Int Arch Allergy Appl Immunol. 1970;39(5-6):511-39 PMID: 4992636
Letter: Genetic control of natural resistance to Leishmania donovani.
Nature. 1974 Jul 26;250(464):353-4 PMID: 4852791
Genetics of resistance to infection with Salmonella typhimurium in mice.
J Infect Dis. 1976 Jan;133(1):72-8 PMID: 1107437
Regulation of Leishmania populations within the host. II. genetic control of acute susceptibility of mice to Leishmania donovani infection.
Clin Exp Immunol. 1977 Oct;30(1):130-40 PMID: 606434
Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse.
Clin Exp Immunol. 1979 Jul;37(1):7-14 PMID: 290436
Control of natural resistance to Salmonella typhimurium and Leishmania donovani in mice by closely linked but distinct genetic loci.
Nature. 1980 Oct 2;287(5781):440-2 PMID: 7001248
Genetics of susceptibility to pristane-induced plasmacytomas in BALB/cAn: reduced susceptibility in BALB/cJ with a brief description of pristane-induced arthritis.
J Immunol. 1981 Oct;127(4):1591-5 PMID: 7276572
Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice.
J Immunol. 1981 Dec;127(6):2417-21 PMID: 6795274
Genetic regulation of resistance to intracellular pathogens.
Nature. 1982 Jun 10;297(5866):506-9 PMID: 7045675
Are the Lsh and Ity disease resistance genes at one locus on mouse chromosome 1?
Nature. 1982 Jun 10;297(5866):510-1 PMID: 7045676
Position on mouse chromosome 1 of a gene that controls resistance to Salmonella typhimurium.
Infect Immun. 1982 Jun;36(3):1257-60 PMID: 7047397
Host genetics and tropical disease.
Trans R Soc Trop Med Hyg. 1982;76(2):155-6 PMID: 6808718

Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.40.3.1234-1235.1983

Published

1983-06-00

Pages

1234-5

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC348184

Subset

Grants

PHS HHS · 17754 · United States

PHS HHS · 18693 · United States

PHS HHS · 5389 · United States

External Links

PubMed source DOI: 10.1128/iai.40.3.1234-1235.1983 PMC Full Text View journal details

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A BALB/c congenic strain of mice that carries a genetic locus (Ityr) controlling resistance to intracellular parasites.

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