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PMID: 290436 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse.

Clinical and experimental immunology ·Vol. 37 ·No. 1 ·1979-07-00 ·Pages 7-14

Bradley DJ, Taylor BA, Blackwell J, Evans EP, Freeman J

Abstract

Acute susceptibility of the mouse to Leishmania donovani is largely determined by a single locus designated Lsh. Linkage between the Lsh locus and the Chromosome 1 marker Id-1 was detected using several sets of recombinant inbred strains. Chromosome 1 linkage was confirmed in backcross generations using isoenzymes and a cytogenetic marker. The data indicate that the gene order is centromere-Lsh-Id-1-ln-Dip-1. The estimated recombination frequency between Lsh and Id-1 is 0.12 +/- 0.04. This mapping is away from the known histocompatibility loci.

MeSH Terms

Alleles Animals Chromosome Mapping Crosses, Genetic Genetic Linkage Genetic Markers Leishmaniasis, Visceral/genetics,immunology Mice Mice, Inbred Strains Recombination, Genetic

Chemicals

Genetic Markers

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Bradley D J

Taylor B A

Blackwell J

Evans E P

Freeman J

References (16)

16 references, click to expand

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Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

Published

1979-07-00

Pages

7-14

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1537668

Subset

External Links

PubMed source PMC Full Text View journal details

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Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse.

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