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PMID: 6334307 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Vaccinia virus 19-kilodalton protein: relationship to several mammalian proteins, including two growth factors.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 81 ·No. 23 ·1984-12-00 ·Pages 7363-7

Blomquist MC, Hunt LT, Barker WC

Abstract

We observed two unusual patterns of cysteine and glycine residues in transforming growth factor type 1 (TGF1); our computer search found only one other protein, the 19-kilodalton early protein of vaccinia virus, having both patterns. The sequences of epidermal growth factor (EGF) and of the light chains from several components of the blood coagulation system also have one of the patterns, but gaps are required to adjust conserved cysteine and glycine residues in the second pattern. We used several computer analyses to confirm these relationships; the 19-kilodalton protein appears to be related to TGF1 and EGF to the same degree that they are related to each other; all three are more distantly related to the coagulation factors. An evolutionary scheme is presented for these proteins. We suggest that the conservation of cysteine residues, which form the disulfide bonds present in the active EGF molecule, may extend to conservation of disulfide bonds in these other proteins. We also suggest that the structural similarities may be correlated with a protein-binding capability.

MeSH Terms
Amino Acid Sequence Animals Biological Evolution Blood Coagulation Factors/genetics Cattle Epidermal Growth Factor/genetics Growth Substances/genetics Humans Macromolecular Substances Mice Molecular Weight Peptides/genetics Rats Software Species Specificity Transforming Growth Factors Vaccinia virus/genetics Viral Proteins/genetics
Chemicals
Blood Coagulation Factors Growth Substances Macromolecular Substances Peptides Viral Proteins Epidermal Growth Factor Transforming Growth Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Blomquist M C
Hunt L T
Barker W C
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44 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.81.23.7363
Published
1984-12-00
Pages
7363-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC392146
Subset
IM
Grants
NIGMS NIH HHS · GM-08710 · United States
NICHD NIH HHS · HD-09547 · United States
NCRR NIH HHS · RR-01821 · United States
External Links
PubMed source DOI: 10.1073/pnas.81.23.7363 PMC Full Text View journal details
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